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10.1186/s12931-020-01546-2 http://scihub22266oqcxt.onion/10.1186/s12931-020-01546-2 33087116!7575703!33087116     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Respir+Res 2020 ; 21 (1): 276 Nephropedia Template TP {{tp|p=33087116|t=2020. Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients performance: a prospective observational cohort study |pdf=|usr=}}{{33087116}} gab.com Text Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients performance: a prospective observational cohort study JO: Respir Res http://www.kidney.de/pget.php?&tw=1&pmid=33087116 #FOAvip BACKGROUND: Severe coronavirus disease 2019 (COVID-19) is frequently associated with hyperinflammation and hyperferritinemia. The latter is related to increased mortality in COVID-19. Still, it is not clear if iron dysmetabolism is mechanistically linked to COVID-19 pathobiology. METHODS: We herein present data from the ongoing prospective, multicentre, observational CovILD cohort study (ClinicalTrials.gov number, NCT04416100), which systematically follows up patients after COVID-19. 109 participants were evaluated 60 days after onset of first COVID-19 symptoms including clinical examination, chest computed tomography and laboratory testing. RESULTS: We investigated subjects with mild to critical COVID-19, of which the majority received hospital treatment. 60 days after disease onset, 30% of subjects still presented with iron deficiency and 9% had anemia, mostly categorized as anemia of inflammation. Anemic patients had increased levels of inflammation markers such as interleukin-6 and C-reactive protein and survived a more severe course of COVID-19. Hyperferritinemia was still present in 38% of all individuals and was more frequent in subjects with preceding severe or critical COVID-19. Analysis of the mRNA expression of peripheral blood mononuclear cells demonstrated a correlation of increased ferritin and cytokine mRNA expression in these patients. Finally, persisting hyperferritinemia was significantly associated with severe lung pathologies in computed tomography scans and a decreased performance status as compared to patients without hyperferritinemia. DISCUSSION: Alterations of iron homeostasis can persist for at least two months after the onset of COVID-19 and are closely associated with non-resolving lung pathologies and impaired physical performance. Determination of serum iron parameters may thus be a easy to access measure to monitor the resolution of COVID-19. TRIAL REGISTRATION: ClinicalTrials.gov number: NCT04416100. Twit Text FOAVip Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients performance: a prospective observational cohort study ????Respir Res http://www.kidney.de/pget.php?&tw=1&pmid=33087116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33087116 #FOAvip English Wikipedia <ref>{{Cite pmid|33087116}}</ref> Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients performance: a prospective observational cohort study #MMPMID33087116 Sonnweber T; Boehm A; Sahanic S; Pizzini A; Aichner M; Sonnweber B; Kurz K; Koppelstatter S; Haschka D; Petzer V; Hilbe R; Theurl M; Lehner D; Nairz M; Puchner B; Luger A; Schwabl C; Bellmann-Weiler R; Woll E; Widmann G; Tancevski I; Judith-Loffler-Ragg; Weiss G Respir Res 2020[Oct]; 21 (1): 276 PMID33087116show ga BACKGROUND: Severe coronavirus disease 2019 (COVID-19) is frequently associated with hyperinflammation and hyperferritinemia. The latter is related to increased mortality in COVID-19. Still, it is not clear if iron dysmetabolism is mechanistically linked to COVID-19 pathobiology. METHODS: We herein present data from the ongoing prospective, multicentre, observational CovILD cohort study (ClinicalTrials.gov number, NCT04416100), which systematically follows up patients after COVID-19. 109 participants were evaluated 60 days after onset of first COVID-19 symptoms including clinical examination, chest computed tomography and laboratory testing. RESULTS: We investigated subjects with mild to critical COVID-19, of which the majority received hospital treatment. 60 days after disease onset, 30% of subjects still presented with iron deficiency and 9% had anemia, mostly categorized as anemia of inflammation. Anemic patients had increased levels of inflammation markers such as interleukin-6 and C-reactive protein and survived a more severe course of COVID-19. Hyperferritinemia was still present in 38% of all individuals and was more frequent in subjects with preceding severe or critical COVID-19. Analysis of the mRNA expression of peripheral blood mononuclear cells demonstrated a correlation of increased ferritin and cytokine mRNA expression in these patients. Finally, persisting hyperferritinemia was significantly associated with severe lung pathologies in computed tomography scans and a decreased performance status as compared to patients without hyperferritinemia. DISCUSSION: Alterations of iron homeostasis can persist for at least two months after the onset of COVID-19 and are closely associated with non-resolving lung pathologies and impaired physical performance. Determination of serum iron parameters may thus be a easy to access measure to monitor the resolution of COVID-19. TRIAL REGISTRATION: ClinicalTrials.gov number: NCT04416100. |*Homeostasis[MESH] |Adult[MESH] |Aged[MESH] |Anemia/etiology[MESH] |C-Reactive Protein/analysis[MESH] |COVID-19[MESH] |Cohort Studies[MESH] |Coronavirus Infections/*complications/*metabolism/physiopathology[MESH] |Female[MESH] |Ferritins/blood[MESH] |Follow-Up Studies[MESH] |Humans[MESH] |Inflammation/etiology/metabolism[MESH] |Interleukin-6/blood[MESH] |Iron/*metabolism[MESH] |Lung Diseases/*etiology/*metabolism/physiopathology[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/metabolism[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/*metabolism/physiopathology[MESH] |Prospective Studies[MESH]Persisting alterations of iron homeostasis in COVID-19 are associated (epmc).pdf DeepDyve Pubget Overpricing