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The potential use of ABO blood group system for risk stratification of COVID-19 #MMPMID33086161
AbdelMassih AF; Mahrous R; Taha A; Saud A; Osman A; Kamel B; Yacoub E; Menshawey E; Ismail HA; Aita L; Dous M; Saad M; AbdelAziz M; Zaghar M; Shebl N; El-Husseiny N; Fahmy N; Hegazy N; Khalid O; Saad O; Afdal P; Menshawey R; Husseiny R; Sherien S; Salama S; Gad S; Ali S; Maalim S; Ismail S; ElHefnawi Y; Aziz Y; Fouda R
Med Hypotheses 2020[Dec]; 145 (ä): 110343 PMID33086161show ga
ABO blood groups is a cheap and affordable test that can be immediately retrieved from COVID-19 patients at the diagnosis. There is increasing evidence that non-O blood groups have both higher susceptibility and higher severity of COVID-19 infections. The reason behind such relationship seems elusive. Regarding susceptibility, Non-O individuals have Anti-A antibodies which can prevent viral entry across ACE-2 receptors, moreover, Non-O individuals are at higher risk of autoimmunity, hypercoagulable state, and dysbiosis resulting in an augmented tendency for vascular inflammatory sequelae of COVID-19. We can conclude, on the diagnostic level, that ABO blood groups can be potentially used for risk stratification of affected COVID-19 patients, to anticipate the deterioration of patients at higher risk for complications. On a therapeutic level, plasma from normal O blood group individuals might potentially replace the use of convalescent serum for the treatment of COVID-19.