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10.1139/gen-2020-0124

http://scihub22266oqcxt.onion/10.1139/gen-2020-0124
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33086021!ä!33086021

suck abstract from ncbi


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pmid33086021      Genome 2021 ; 64 (4): 386-399
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  • Epigenetic regulation of ACE2, the receptor of the SARS-CoV-2 virus(1) #MMPMID33086021
  • Beacon TH; Delcuve GP; Davie JR
  • Genome 2021[Apr]; 64 (4): 386-399 PMID33086021show ga
  • The angiotensin-converting enzyme 2 (ACE2) is the receptor for the three coronaviruses HCoV-NL63, SARS-CoV, and SARS-CoV-2. ACE2 is involved in the regulation of the renin-angiotensin system and blood pressure. ACE2 is also involved in the regulation of several signaling pathways, including integrin signaling. ACE2 expression is regulated transcriptionally and post-transcriptionally. The expression of the gene is regulated by two promoters, with usage varying among tissues. ACE2 expression is greatest in the small intestine, kidney, and heart and detectable in a variety of tissues and cell types. Herein we review the chemical and mechanical signal transduction pathways regulating the expression of the ACE2 gene and the epigenetic/chromatin features of the expressed gene.
  • |*Epigenesis, Genetic[MESH]
  • |Angiotensin-Converting Enzyme 2/*genetics[MESH]
  • |COVID-19[MESH]
  • |Gene Expression Regulation[MESH]
  • |Humans[MESH]
  • |Promoter Regions, Genetic[MESH]
  • |Protein Processing, Post-Translational[MESH]
  • |Receptors, Virus/*genetics[MESH]
  • |Renin-Angiotensin System[MESH]
  • |SARS-CoV-2[MESH]


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