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10.1172/JCI144115 http://scihub22266oqcxt.onion/10.1172/JCI144115 33085654!7685716!33085654     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2020 ; 130 (12): 6204-6213 Nephropedia Template TP {{tp|p=33085654|t=2020. Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity |pdf=|usr=}}{{33085654}} gab.com Text Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33085654 #FOAvip Human coronaviruses (hCoVs) cause severe respiratory illness in the elderly. Age-related impairments in innate immunity and suboptimal virus-specific T cell and antibody responses are believed to cause severe disease upon respiratory virus infections. This phenomenon has recently received increased attention, as elderly patients are at substantially elevated risk for severe COVID-19 disease and experience increased rates of mortality following SARS-CoV-2 infection compared with younger populations. However, the basis for age-related fatal pneumonia following pathogenic hCoVs is not well understood. In this Review, we provide an overview of our current understanding of hCoV-induced fatal pneumonia in the elderly. We describe host immune response to hCoV infections derived from studies of young and aged animal models and discuss the potential role of age-associated increases in sterile inflammation (inflammaging) and virus-induced dysregulated inflammation in causing age-related severe disease. We also highlight the existing gaps in our knowledge about virus replication and host immune responses to hCoV infection in young and aged individuals. Twit Text FOAVip Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33085654 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33085654 #FOAvip English Wikipedia <ref>{{Cite pmid|33085654}}</ref> Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity #MMPMID33085654 Channappanavar R; Perlman S J Clin Invest 2020[Dec]; 130 (12): 6204-6213 PMID33085654show ga Human coronaviruses (hCoVs) cause severe respiratory illness in the elderly. Age-related impairments in innate immunity and suboptimal virus-specific T cell and antibody responses are believed to cause severe disease upon respiratory virus infections. This phenomenon has recently received increased attention, as elderly patients are at substantially elevated risk for severe COVID-19 disease and experience increased rates of mortality following SARS-CoV-2 infection compared with younger populations. However, the basis for age-related fatal pneumonia following pathogenic hCoVs is not well understood. In this Review, we provide an overview of our current understanding of hCoV-induced fatal pneumonia in the elderly. We describe host immune response to hCoV infections derived from studies of young and aged animal models and discuss the potential role of age-associated increases in sterile inflammation (inflammaging) and virus-induced dysregulated inflammation in causing age-related severe disease. We also highlight the existing gaps in our knowledge about virus replication and host immune responses to hCoV infection in young and aged individuals. |*Immunity, Innate[MESH] |Aging/*immunology[MESH] |Animals[MESH] |COVID-19/*immunology[MESH] |Disease Models, Animal[MESH] |Disease Susceptibility[MESH] |Humans[MESH] |Inflammation/immunology/virology[MESH] |Risk Factors[MESH] |SARS-CoV-2/*immunology[MESH]Age-related susceptibility to coronavirus infections: role of impaired(epmc).pdf DeepDyve Pubget Overpricing