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10.1093/clinchem/hvaa262

http://scihub22266oqcxt.onion/10.1093/clinchem/hvaa262
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33084854!7665417!33084854
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suck abstract from ncbi


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pmid33084854      Clin+Chem 2021 ; 67 (2): 404-414
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  • Commercial Serology Assays Predict Neutralization Activity against SARS-CoV-2 #MMPMID33084854
  • Suhandynata RT; Hoffman MA; Huang D; Tran JT; Kelner MJ; Reed SL; McLawhon RW; Voss JE; Nemazee D; Fitzgerald RL
  • Clin Chem 2021[Jan]; 67 (2): 404-414 PMID33084854show ga
  • BACKGROUND: It is unknown whether a positive serology result correlates with protective immunity against SARS-CoV-2. There are also concerns regarding the low positive predictive value of SARS-CoV-2 serology tests, especially when testing populations with low disease prevalence. METHODS: A neutralization assay was validated in a set of PCR-confirmed positive specimens and in a negative cohort. In addition, 9530 specimens were screened using the Diazyme SARS-CoV-2 IgG serology assay and all positive results (N = 164 individuals) were reanalyzed using the neutralization assay, the Roche total immunoglobin assay, and the Abbott IgG assay. The relationship between the magnitude of a positive SARS-CoV-2 serology result and neutralizing activity was determined. Neutralizing antibody titers (50% inhibitory dilution, ID50) were also longitudinally monitored in patients confirmed to have SARS-CoV-2 by PCR. RESULTS: The SARS-CoV-2 neutralization assay had a positive percentage agreement (PPA) of 96.6% with a SARS-CoV-2 PCR test and a negative percentage agreement (NPA) of 98.0% across 100 negative control individuals. ID50 neutralization titers positively correlated with all 3 clinical serology platforms. Longitudinal monitoring of hospitalized PCR-confirmed patients with COVID-19 demonstrated they made high neutralization titers against SARS-CoV-2. PPA between the Diazyme IgG assay alone and the neutralization assay was 50.6%, while combining the Diazyme IgG assay with either the Roche or Abbott platforms increased the PPA to 79.2 and 78.4%, respectively. CONCLUSIONS: These 3 clinical serology assays positively correlate with SARS-CoV-2 neutralization activity observed in patients with COVID-19. All patients confirmed SARS-CoV-2 positive by PCR develop neutralizing antibodies.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Antibodies, Neutralizing/*blood/immunology[MESH]
  • |Antibodies, Viral/*blood/immunology[MESH]
  • |COVID-19 Serological Testing/*methods/statistics & numerical data[MESH]
  • |COVID-19/immunology[MESH]
  • |Cohort Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Polymerase Chain Reaction[MESH]
  • |Regression Analysis[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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