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10.1093/infdis/jiaa660

http://scihub22266oqcxt.onion/10.1093/infdis/jiaa660
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33083826!7797748!33083826
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suck abstract from ncbi


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pmid33083826      J+Infect+Dis 2021 ; 223 (1): 19-22
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  • Associations Between Genetically Predicted Protein Levels and COVID-19 Severity #MMPMID33083826
  • Zhu J; Wu C; Wu L
  • J Infect Dis 2021[Jan]; 223 (1): 19-22 PMID33083826show ga
  • It is critical to identify potential causal targets for SARS-CoV-2, which may guide drug repurposing options. We assessed the associations between genetically predicted protein levels and COVID-19 severity. Leveraging data from the COVID-19 Host Genetics Initiative comparing 6492 hospitalized COVID-19 patients and 1 012 809 controls, we identified 18 proteins with genetically predicted levels to be associated with COVID-19 severity at a false discovery rate of <0.05, including 12 that showed an association even after Bonferroni correction. Of the 18 proteins, 6 showed positive associations and 12 showed inverse associations. In conclusion, we identified 18 candidate proteins for COVID-19 severity.
  • |*Genetic Association Studies[MESH]
  • |Blood Proteins/*analysis[MESH]
  • |COVID-19/*diagnosis/*genetics[MESH]
  • |Case-Control Studies[MESH]
  • |Humans[MESH]


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