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10.1038/s41598-020-74598-5

http://scihub22266oqcxt.onion/10.1038/s41598-020-74598-5
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suck abstract from ncbi


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pmid33082395      Sci+Rep 2020 ; 10 (1): 17772
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  • Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19 #MMPMID33082395
  • Valyaeva AA; Zharikova AA; Kasianov AS; Vassetzky YS; Sheval EV
  • Sci Rep 2020[Oct]; 10 (1): 17772 PMID33082395show ga
  • SARS-CoV-2 can infiltrate the lower respiratory tract, resulting in severe respiratory failure and a high death rate. Normally, the airway and alveolar epithelium can be rapidly reconstituted by multipotent stem cells after episodes of infection. Here, we analyzed published RNA-seq datasets and demonstrated that cells of four different lung epithelial stem cell types express SARS-CoV-2 entry factors, including Ace2. Thus, stem cells can be potentially infected by SARS-CoV-2, which may lead to defects in regeneration capacity partially accounting for the severity of SARS-CoV-2 infection and its consequences.
  • |*Virus Internalization[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Betacoronavirus/isolation & purification/*physiology[MESH]
  • |COVID-19[MESH]
  • |Cell Differentiation[MESH]
  • |Cell Line[MESH]
  • |Coronavirus Infections/pathology/virology[MESH]
  • |Humans[MESH]
  • |Lung/cytology[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A/metabolism[MESH]
  • |Pneumonia, Viral/pathology/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Serine Endopeptidases/metabolism[MESH]
  • |Stem Cells/cytology/metabolism/virology[MESH]


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