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10.1038/s41467-020-19056-6

http://scihub22266oqcxt.onion/10.1038/s41467-020-19056-6
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33082342!7576792!33082342
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suck abstract from ncbi


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pmid33082342      Nat+Commun 2020 ; 11 (1): 5284
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  • A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics #MMPMID33082342
  • Lyngbakken MN; Berdal JE; Eskesen A; Kvale D; Olsen IC; Rueegg CS; Rangberg A; Jonassen CM; Omland T; Rosjo H; Dalgard O
  • Nat Commun 2020[Oct]; 11 (1): 5284 PMID33082342show ga
  • Here, we randomized 53 patients hospitalized with coronavirus disease 2019 (COVID-19) to hydroxychloroquine therapy (at a dose of 400 mg twice daily for seven days) in addition to standard care or standard care alone (ClinicalTrials.gov Identifier, NCT04316377). All severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients 18 years of age or older were eligible for study inclusion if they had moderately severe COVID-19 at admission. Treatment with hydroxychloroquine did not result in a significantly greater rate of decline in SARS-CoV-2 oropharyngeal viral load compared to standard care alone during the first five days. Our results suggest no important antiviral effect of hydroxychloroquine in humans infected with SARS-CoV-2.
  • |Aged[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Betacoronavirus/*drug effects[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/*drug therapy/mortality[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/*therapeutic use[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/mortality[MESH]
  • |SARS-CoV-2[MESH]
  • |Treatment Outcome[MESH]


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