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10.1126/science.abd3072 http://scihub22266oqcxt.onion/10.1126/science.abd3072 33082294!7612957!33082294     free     free     free       Science 2020 ; 370 (6518): 861-865 Nephropedia Template TP {{tp|p=33082294|t=2020. Neuropilin-1 is a host factor for SARS-CoV-2 infection |pdf=|usr=}}{{33082294}} gab.com Text Neuropilin-1 is a host factor for SARS-CoV-2 infection JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=33082294 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), uses the viral spike (S) protein for host cell attachment and entry. The host protease furin cleaves the full-length precursor S glycoprotein into two associated polypeptides: S1 and S2. Cleavage of S generates a polybasic Arg-Arg-Ala-Arg carboxyl-terminal sequence on S1, which conforms to a C-end rule (CendR) motif that binds to cell surface neuropilin-1 (NRP1) and NRP2 receptors. We used x-ray crystallography and biochemical approaches to show that the S1 CendR motif directly bound NRP1. Blocking this interaction by RNA interference or selective inhibitors reduced SARS-CoV-2 entry and infectivity in cell culture. NRP1 thus serves as a host factor for SARS-CoV-2 infection and may potentially provide a therapeutic target for COVID-19. Twit Text FOAVip Neuropilin-1 is a host factor for SARS-CoV-2 infection ????Science http://www.kidney.de/pget.php?&tw=1&pmid=33082294 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33082294 #FOAvip English Wikipedia <ref>{{Cite pmid|33082294}}</ref> Neuropilin-1 is a host factor for SARS-CoV-2 infection #MMPMID33082294 Daly JL; Simonetti B; Klein K; Chen KE; Williamson MK; Anton-Plagaro C; Shoemark DK; Simon-Gracia L; Bauer M; Hollandi R; Greber UF; Horvath P; Sessions RB; Helenius A; Hiscox JA; Teesalu T; Matthews DA; Davidson AD; Collins BM; Cullen PJ; Yamauchi Y Science 2020[Nov]; 370 (6518): 861-865 PMID33082294show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), uses the viral spike (S) protein for host cell attachment and entry. The host protease furin cleaves the full-length precursor S glycoprotein into two associated polypeptides: S1 and S2. Cleavage of S generates a polybasic Arg-Arg-Ala-Arg carboxyl-terminal sequence on S1, which conforms to a C-end rule (CendR) motif that binds to cell surface neuropilin-1 (NRP1) and NRP2 receptors. We used x-ray crystallography and biochemical approaches to show that the S1 CendR motif directly bound NRP1. Blocking this interaction by RNA interference or selective inhibitors reduced SARS-CoV-2 entry and infectivity in cell culture. NRP1 thus serves as a host factor for SARS-CoV-2 infection and may potentially provide a therapeutic target for COVID-19. |*Virus Internalization[MESH] |Amino Acid Motifs[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Antibodies, Monoclonal/immunology/metabolism[MESH] |Betacoronavirus/*physiology[MESH] |COVID-19[MESH] |Caco-2 Cells[MESH] |Coronavirus Infections/virology[MESH] |Crystallography, X-Ray[MESH] |Furin/metabolism[MESH] |HeLa Cells[MESH] |Humans[MESH] |Mutagenesis, Site-Directed[MESH] |Neuropilin-1/antagonists & inhibitors/chemistry/genetics/*metabolism[MESH] |Pandemics[MESH] |Peptide Fragments/chemistry/metabolism[MESH] |Peptidyl-Dipeptidase A/genetics/metabolism[MESH] |Pneumonia, Viral/virology[MESH] |Protein Binding[MESH] |Protein Interaction Domains and Motifs[MESH] |RNA Interference[MESH] |SARS-CoV-2[MESH]Neuropilin-1 is a host factor for SARS-CoV-2 infection (epmc).pdf DeepDyve Pubget Overpricing