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10.1126/science.abd2985

http://scihub22266oqcxt.onion/10.1126/science.abd2985
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33082293!7857391!33082293
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suck abstract from ncbi


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pmid33082293      Science 2020 ; 370 (6518): 856-860
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  • Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity #MMPMID33082293
  • Cantuti-Castelvetri L; Ojha R; Pedro LD; Djannatian M; Franz J; Kuivanen S; van der Meer F; Kallio K; Kaya T; Anastasina M; Smura T; Levanov L; Szirovicza L; Tobi A; Kallio-Kokko H; Osterlund P; Joensuu M; Meunier FA; Butcher SJ; Winkler MS; Mollenhauer B; Helenius A; Gokce O; Teesalu T; Hepojoki J; Vapalahti O; Stadelmann C; Balistreri G; Simons M
  • Science 2020[Nov]; 370 (6518): 856-860 PMID33082293show ga
  • The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For many viruses, tissue tropism is determined by the availability of virus receptors and entry cofactors on the surface of host cells. In this study, we found that neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, an effect blocked by a monoclonal blocking antibody against NRP1. A SARS-CoV-2 mutant with an altered furin cleavage site did not depend on NRP1 for infectivity. Pathological analysis of olfactory epithelium obtained from human COVID-19 autopsies revealed that SARS-CoV-2 infected NRP1-positive cells facing the nasal cavity. Our data provide insight into SARS-CoV-2 cell infectivity and define a potential target for antiviral intervention.
  • |*Virus Internalization[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Animals[MESH]
  • |Antibodies, Monoclonal/immunology[MESH]
  • |Betacoronavirus/genetics/*physiology[MESH]
  • |COVID-19[MESH]
  • |Caco-2 Cells[MESH]
  • |Coronavirus Infections/*virology[MESH]
  • |Female[MESH]
  • |HEK293 Cells[MESH]
  • |Host Microbial Interactions[MESH]
  • |Humans[MESH]
  • |Lung/metabolism[MESH]
  • |Male[MESH]
  • |Metal Nanoparticles[MESH]
  • |Mice[MESH]
  • |Mice, Inbred C57BL[MESH]
  • |Mutation[MESH]
  • |Neuropilin-1/chemistry/genetics/immunology/*metabolism[MESH]
  • |Neuropilin-2/metabolism[MESH]
  • |Olfactory Mucosa/metabolism/virology[MESH]
  • |Pandemics[MESH]
  • |Peptide Fragments/metabolism[MESH]
  • |Peptidyl-Dipeptidase A/genetics/metabolism[MESH]
  • |Pneumonia, Viral/*virology[MESH]
  • |Protein Binding[MESH]
  • |Protein Domains[MESH]
  • |Respiratory Mucosa/metabolism[MESH]
  • |SARS-CoV-2[MESH]
  • |Serine Endopeptidases/genetics/metabolism[MESH]


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