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10.1088/1752-7163/abc302

http://scihub22266oqcxt.onion/10.1088/1752-7163/abc302
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33080582!ä!33080582

suck abstract from ncbi


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pmid33080582      J+Breath+Res 2020 ; 15 (1): 014001
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  • Nitric oxide s physiologic effects and potential as a therapeutic agent against COVID-19 #MMPMID33080582
  • Ricciardolo FLM; Bertolini F; Carriero V; Hogman M
  • J Breath Res 2020[Dec]; 15 (1): 014001 PMID33080582show ga
  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for COVID-19 pneumonia, a pandemic that precipitates huge pressures on the world's social and economic systems. Disease severity varies among individuals. SARS-CoV-2 infection can be associated with e.g. flu-like symptoms, dyspnoea, severe interstitial pneumonia, acute respiratory distress syndrome, multiorgan dysfunction, and generalized coagulopathy. Nitric oxide (NO), is a small signal molecule that impacts pleiotropic functions in human physiology, which can be involved in the significant effects of COVID-19 infection. NO is a neurotransmitter involved in the neural olfactory processes in the central nervous system, and some infected patients have reported anosmia as a symptom. Additionally, NO is a well-known vasodilator, important coagulation mediator, anti-microbial effector and inhibitor of SARS-CoV replication. Exhaled NO is strongly related to the type-2 inflammatory response found in asthma, which has been suggested to be protective against SARS-CoV-2 infection. Several reports indicate that the use of inhaled NO has been an effective therapy during this pandemic since the ventilation-perfusion ratio in COVID-19 patients improved afterwards and they did not require mechanical ventilation. The aim of this mini-review is to summarize relevant actions of NO that could be beneficial in the treatment of COVID-19.
  • |Adult[MESH]
  • |COVID-19/*metabolism/*therapy/virology[MESH]
  • |Humans[MESH]
  • |Nitric Oxide/*administration & dosage/*metabolism[MESH]


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