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10.1016/j.jid.2020.09.010 http://scihub22266oqcxt.onion/10.1016/j.jid.2020.09.010 33080304!7568177!33080304     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33080304&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Invest+Dermatol 2021 ; 141 (4): 722-726 Nephropedia Template TP {{tp|p=33080304|t=2021. iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility |pdf=|usr=}}{{33080304}} gab.com Text iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility JO: J Invest Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=33080304 #FOAvip The palmoplantar epidermis is a specialized area of the skin that undergoes high levels of mechanical stress. The palmoplantar keratinization and esophageal cancer syndrome, tylosis with esophageal cancer, is linked to mutations in RHBDF2 encoding the proteolytically inactive rhomboid protein, iRhom2. Subsequently, iRhom2 was found to affect palmoplantar thickening to modulate the stress keratin response and to mediate context-dependent stress pathways by p63. iRhom2 is also a direct regulator of the sheddase, ADAM17, and the antiviral adaptor protein, stimulator of IFN genes. In this perspective, the pleiotropic functions of iRhom2 are discussed with respect to the skin, inflammation, and the antiviral response. Twit Text FOAVip iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility ????J Invest Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=33080304 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33080304 #FOAvip English Wikipedia <ref>{{Cite pmid|33080304}}</ref> iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility #MMPMID33080304 Chao-Chu J; Murtough S; Zaman N; Pennington DJ; Blaydon DC; Kelsell DP J Invest Dermatol 2021[Apr]; 141 (4): 722-726 PMID33080304show ga The palmoplantar epidermis is a specialized area of the skin that undergoes high levels of mechanical stress. The palmoplantar keratinization and esophageal cancer syndrome, tylosis with esophageal cancer, is linked to mutations in RHBDF2 encoding the proteolytically inactive rhomboid protein, iRhom2. Subsequently, iRhom2 was found to affect palmoplantar thickening to modulate the stress keratin response and to mediate context-dependent stress pathways by p63. iRhom2 is also a direct regulator of the sheddase, ADAM17, and the antiviral adaptor protein, stimulator of IFN genes. In this perspective, the pleiotropic functions of iRhom2 are discussed with respect to the skin, inflammation, and the antiviral response. |ADAM17 Protein/metabolism[MESH] |Animals[MESH] |Carrier Proteins/genetics/metabolism[MESH] |Dermatitis/genetics/*immunology[MESH] |Disease Models, Animal[MESH] |Epidermis/immunology/*pathology[MESH] |Esophageal Neoplasms/*genetics/immunology/pathology[MESH] |Foot[MESH] |Gene Expression Regulation/immunology[MESH] |Hand[MESH] |Host Microbial Interactions/genetics/immunology[MESH] |Humans[MESH] |Intracellular Signaling Peptides and Proteins/*genetics/metabolism[MESH] |Keratinocytes/immunology/metabolism[MESH] |Keratins/metabolism[MESH] |Keratoderma, Palmoplantar/*genetics/immunology/pathology[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Mutation[MESH] |Signal Transduction/genetics/immunology[MESH] |Skin Diseases, Viral/genetics/*immunology/virology[MESH] |Transcription Factors/metabolism[MESH]iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral (epmc).pdf DeepDyve Pubget Overpricing