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10.1016/j.cell.2020.10.004 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.10.004 33080218!7543886!33080218     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 183 (5): 1325-1339.e21 Nephropedia Template TP {{tp|p=33080218|t=2020. SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses |pdf=|usr=}}{{33080218}} gab.com Text SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33080218 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID-19). Despite the urgent need, we still do not fully understand the molecular basis of SARS-CoV-2 pathogenesis. Here, we comprehensively define the interactions between SARS-CoV-2 proteins and human RNAs. NSP16 binds to the mRNA recognition domains of the U1 and U2 splicing RNAs and acts to suppress global mRNA splicing upon SARS-CoV-2 infection. NSP1 binds to 18S ribosomal RNA in the mRNA entry channel of the ribosome and leads to global inhibition of mRNA translation upon infection. Finally, NSP8 and NSP9 bind to the 7SL RNA in the signal recognition particle and interfere with protein trafficking to the cell membrane upon infection. Disruption of each of these essential cellular functions acts to suppress the interferon response to viral infection. Our results uncover a multipronged strategy utilized by SARS-CoV-2 to antagonize essential cellular processes to suppress host defenses. Twit Text FOAVip SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33080218 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33080218 #FOAvip English Wikipedia <ref>{{Cite pmid|33080218}}</ref> SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses #MMPMID33080218 Banerjee AK; Blanco MR; Bruce EA; Honson DD; Chen LM; Chow A; Bhat P; Ollikainen N; Quinodoz SA; Loney C; Thai J; Miller ZD; Lin AE; Schmidt MM; Stewart DG; Goldfarb D; De Lorenzo G; Rihn SJ; Voorhees RM; Botten JW; Majumdar D; Guttman M Cell 2020[Nov]; 183 (5): 1325-1339.e21 PMID33080218show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID-19). Despite the urgent need, we still do not fully understand the molecular basis of SARS-CoV-2 pathogenesis. Here, we comprehensively define the interactions between SARS-CoV-2 proteins and human RNAs. NSP16 binds to the mRNA recognition domains of the U1 and U2 splicing RNAs and acts to suppress global mRNA splicing upon SARS-CoV-2 infection. NSP1 binds to 18S ribosomal RNA in the mRNA entry channel of the ribosome and leads to global inhibition of mRNA translation upon infection. Finally, NSP8 and NSP9 bind to the 7SL RNA in the signal recognition particle and interfere with protein trafficking to the cell membrane upon infection. Disruption of each of these essential cellular functions acts to suppress the interferon response to viral infection. Our results uncover a multipronged strategy utilized by SARS-CoV-2 to antagonize essential cellular processes to suppress host defenses. |*Host-Pathogen Interactions[MESH] |*Protein Biosynthesis[MESH] |*RNA Splicing[MESH] |A549 Cells[MESH] |Animals[MESH] |COVID-19/*metabolism/virology[MESH] |Chlorocebus aethiops[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Interferons/metabolism[MESH] |Protein Transport[MESH] |RNA, Messenger/metabolism[MESH] |RNA, Ribosomal, 18S/metabolism[MESH] |RNA, Small Cytoplasmic/chemistry/metabolism[MESH] |SARS-CoV-2/*metabolism[MESH] |Signal Recognition Particle/chemistry/metabolism[MESH] |Vero Cells[MESH]SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to (epmc).pdf DeepDyve Pubget Overpricing