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10.1002/jmv.26612

http://scihub22266oqcxt.onion/10.1002/jmv.26612
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33079389!ä!33079389

suck abstract from ncbi


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pmid33079389      J+Med+Virol 2021 ; 93 (3): 1805-1809
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  • Interpretive discrepancies caused by target values inter-batch variations in chemiluminescence immunoassay for SARS-CoV-2 IgM/IgG by MAGLUMI #MMPMID33079389
  • Selingerova I; Valik D; Gescheidtova L; Sramek V; Cermakova Z; Zdrazilova-Dubska L
  • J Med Virol 2021[Mar]; 93 (3): 1805-1809 PMID33079389show ga
  • Plasma specimens from coronavirus disease 2019 patients were double-tested for anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies by two different batches of MAGLUMI 2019-nCov immunoglobulin M/immunoglobulin G (IgM/IgG) assays to evaluate IgM/IgG levels, qualitative interpretation, antibody kinetics, and linearity of diluted specimen. Here we show that (i) high-level IgM specimens need to be diluted with negative human plasma but not kit diluents and (ii) measured anti-SARS-CoV-2 IgM/IgG concentrations are substantially higher with later marketed immunoassay batch leading to (iii) the change of qualitative interpretation (positive vs. negative) in 12.3% of specimens measured for IgM, (iv) the informative time-course pattern of antibody production only when data from different immunoassay batches are not combined.
  • |Antibodies, Viral/immunology[MESH]
  • |COVID-19 Testing/methods[MESH]
  • |COVID-19/*blood/*immunology[MESH]
  • |Humans[MESH]
  • |Immunoassay/methods[MESH]
  • |Immunoglobulin G/*blood/*immunology[MESH]
  • |Immunoglobulin M/*blood/*immunology[MESH]
  • |Luminescence[MESH]
  • |Luminescent Measurements/methods[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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