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10.1007/s00277-020-04297-8

http://scihub22266oqcxt.onion/10.1007/s00277-020-04297-8
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33079221!7572248!33079221
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suck abstract from ncbi


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pmid33079221      Ann+Hematol 2021 ; 100 (2): 321-336
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  • Prophylaxis, diagnosis and therapy of infections in patients undergoing high-dose chemotherapy and autologous haematopoietic stem cell transplantation 2020 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) #MMPMID33079221
  • Christopeit M; Schmidt-Hieber M; Sprute R; Buchheidt D; Hentrich M; Karthaus M; Penack O; Ruhnke M; Weissinger F; Cornely OA; Maschmeyer G
  • Ann Hematol 2021[Feb]; 100 (2): 321-336 PMID33079221show ga
  • To ensure the safety of high-dose chemotherapy and autologous stem cell transplantation (HDC/ASCT), evidence-based recommendations on infectious complications after HDC/ASCT are given. This guideline not only focuses on patients with haematological malignancies but also addresses the specifics of HDC/ASCT patients with solid tumours or autoimmune disorders. In addition to HBV and HCV, HEV screening is nowadays mandatory prior to ASCT. For patients with HBs antigen and/or anti-HBc antibody positivity, HBV nucleic acid testing is strongly recommended for 6 months after HDC/ASCT or for the duration of a respective maintenance therapy. Prevention of VZV reactivation by vaccination is strongly recommended. Cotrimoxazole for the prevention of Pneumocystis jirovecii is supported. Invasive fungal diseases are less frequent after HDC/ASCT, therefore, primary systemic antifungal prophylaxis is not recommended. Data do not support a benefit of protective room ventilation e.g. HEPA filtration. Thus, AGIHO only supports this technique with marginal strength. Fluoroquinolone prophylaxis is recommended to prevent bacterial infections, although a survival advantage has not been demonstrated.
  • |*Hematopoietic Stem Cell Transplantation[MESH]
  • |Germany[MESH]
  • |Hematologic Neoplasms/*therapy[MESH]
  • |Hematology[MESH]
  • |Hepacivirus/*metabolism[MESH]
  • |Hepatitis B Antibodies/blood[MESH]
  • |Hepatitis B virus/*metabolism[MESH]
  • |Hepatitis B/blood/*prevention & control[MESH]
  • |Hepatitis C/blood/*prevention & control[MESH]
  • |Humans[MESH]
  • |Medical Oncology[MESH]
  • |Pneumocystis carinii/*metabolism[MESH]
  • |Pneumonia, Pneumocystis/blood/*prevention & control[MESH]
  • |Practice Guidelines as Topic[MESH]
  • |RNA, Viral/blood[MESH]
  • |Societies, Medical[MESH]
  • |Transplantation, Autologous[MESH]


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