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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 EMBO+Mol+Med 2020 ; 12 (12): e13001 Nephropedia Template TP
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Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID-19 pneumonia #MMPMID33078545
Gibellini L; De Biasi S; Paolini A; Borella R; Boraldi F; Mattioli M; Lo Tartaro D; Fidanza L; Caro-Maldonado A; Meschiari M; Iadisernia V; Bacca E; Riva G; Cicchetti L; Quaglino D; Guaraldi G; Busani S; Girardis M; Mussini C; Cossarizza A
EMBO Mol Med 2020[Dec]; 12 (12): e13001 PMID33078545show ga
In patients infected by SARS-CoV-2 who experience an exaggerated inflammation leading to pneumonia, monocytes likely play a major role but have received poor attention. Thus, we analyzed peripheral blood monocytes from patients with COVID-19 pneumonia and found that these cells show signs of altered bioenergetics and mitochondrial dysfunction, had a reduced basal and maximal respiration, reduced spare respiratory capacity, and decreased proton leak. Basal extracellular acidification rate was also diminished, suggesting reduced capability to perform aerobic glycolysis. Although COVID-19 monocytes had a reduced ability to perform oxidative burst, they were still capable of producing TNF and IFN-gamma in vitro. A significantly high amount of monocytes had depolarized mitochondria and abnormal mitochondrial ultrastructure. A redistribution of monocyte subsets, with a significant expansion of intermediate/pro-inflammatory cells, and high amounts of immature monocytes were found, along with a concomitant compression of classical monocytes, and an increased expression of inhibitory checkpoints like PD-1/PD-L1. High plasma levels of several inflammatory cytokines and chemokines, including GM-CSF, IL-18, CCL2, CXCL10, and osteopontin, finally confirm the importance of monocytes in COVID-19 immunopathogenesis.
|Adult[MESH]
|Aged[MESH]
|Aged, 80 and over[MESH]
|COVID-19/*pathology/virology[MESH]
|Case-Control Studies[MESH]
|Chemokines/blood[MESH]
|Cytokines/blood[MESH]
|Energy Metabolism/*physiology[MESH]
|Female[MESH]
|Humans[MESH]
|Male[MESH]
|Middle Aged[MESH]
|Mitochondria/*metabolism/ultrastructure[MESH]
|Monocytes/cytology/*metabolism[MESH]
|Programmed Cell Death 1 Receptor/genetics/metabolism[MESH]