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10.15252/emmm.202013001

http://scihub22266oqcxt.onion/10.15252/emmm.202013001
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33078545!7645870!33078545
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suck abstract from ncbi


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pmid33078545      EMBO+Mol+Med 2020 ; 12 (12): e13001
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  • Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID-19 pneumonia #MMPMID33078545
  • Gibellini L; De Biasi S; Paolini A; Borella R; Boraldi F; Mattioli M; Lo Tartaro D; Fidanza L; Caro-Maldonado A; Meschiari M; Iadisernia V; Bacca E; Riva G; Cicchetti L; Quaglino D; Guaraldi G; Busani S; Girardis M; Mussini C; Cossarizza A
  • EMBO Mol Med 2020[Dec]; 12 (12): e13001 PMID33078545show ga
  • In patients infected by SARS-CoV-2 who experience an exaggerated inflammation leading to pneumonia, monocytes likely play a major role but have received poor attention. Thus, we analyzed peripheral blood monocytes from patients with COVID-19 pneumonia and found that these cells show signs of altered bioenergetics and mitochondrial dysfunction, had a reduced basal and maximal respiration, reduced spare respiratory capacity, and decreased proton leak. Basal extracellular acidification rate was also diminished, suggesting reduced capability to perform aerobic glycolysis. Although COVID-19 monocytes had a reduced ability to perform oxidative burst, they were still capable of producing TNF and IFN-gamma in vitro. A significantly high amount of monocytes had depolarized mitochondria and abnormal mitochondrial ultrastructure. A redistribution of monocyte subsets, with a significant expansion of intermediate/pro-inflammatory cells, and high amounts of immature monocytes were found, along with a concomitant compression of classical monocytes, and an increased expression of inhibitory checkpoints like PD-1/PD-L1. High plasma levels of several inflammatory cytokines and chemokines, including GM-CSF, IL-18, CCL2, CXCL10, and osteopontin, finally confirm the importance of monocytes in COVID-19 immunopathogenesis.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/*pathology/virology[MESH]
  • |Case-Control Studies[MESH]
  • |Chemokines/blood[MESH]
  • |Cytokines/blood[MESH]
  • |Energy Metabolism/*physiology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Mitochondria/*metabolism/ultrastructure[MESH]
  • |Monocytes/cytology/*metabolism[MESH]
  • |Programmed Cell Death 1 Receptor/genetics/metabolism[MESH]


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