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10.1038/s41588-020-00732-8 http://scihub22266oqcxt.onion/10.1038/s41588-020-00732-8 33077915!7610354!33077915     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Genet 2020 ; 52 (12): 1294-1302 Nephropedia Template TP {{tp|p=33077915|t=2020. Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option |pdf=|usr=}}{{33077915}} gab.com Text Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=33077915 #FOAvip Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and a regulator of several physiological processes. ACE2 has recently been proposed to be interferon (IFN) inducible, suggesting that SARS-CoV-2 may exploit this phenomenon to enhance viral spread and questioning the efficacy of IFN treatment in coronavirus disease 2019. Using a recent de novo transcript assembly that captured previously unannotated transcripts, we describe a new isoform of ACE2, generated by co-option of intronic retroelements as promoter and alternative exon. The new transcript, termed MIRb-ACE2, exhibits specific expression patterns across the aerodigestive and gastrointestinal tracts and is highly responsive to IFN stimulation. In contrast, canonical ACE2 expression is unresponsive to IFN stimulation. Moreover, the MIRb-ACE2 translation product is a truncated, unstable ACE2 form, lacking domains required for SARS-CoV-2 binding and is therefore unlikely to contribute to or enhance viral infection. Twit Text FOAVip Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=33077915 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33077915 #FOAvip English Wikipedia <ref>{{Cite pmid|33077915}}</ref> Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option #MMPMID33077915 Ng KW; Attig J; Bolland W; Young GR; Major J; Wrobel AG; Gamblin S; Wack A; Kassiotis G Nat Genet 2020[Dec]; 52 (12): 1294-1302 PMID33077915show ga Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and a regulator of several physiological processes. ACE2 has recently been proposed to be interferon (IFN) inducible, suggesting that SARS-CoV-2 may exploit this phenomenon to enhance viral spread and questioning the efficacy of IFN treatment in coronavirus disease 2019. Using a recent de novo transcript assembly that captured previously unannotated transcripts, we describe a new isoform of ACE2, generated by co-option of intronic retroelements as promoter and alternative exon. The new transcript, termed MIRb-ACE2, exhibits specific expression patterns across the aerodigestive and gastrointestinal tracts and is highly responsive to IFN stimulation. In contrast, canonical ACE2 expression is unresponsive to IFN stimulation. Moreover, the MIRb-ACE2 translation product is a truncated, unstable ACE2 form, lacking domains required for SARS-CoV-2 binding and is therefore unlikely to contribute to or enhance viral infection. |Angiotensin-Converting Enzyme 2/*biosynthesis/genetics[MESH] |Animals[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Enzyme Induction[MESH] |Gene Expression Profiling[MESH] |Gene Expression Regulation, Enzymologic[MESH] |Gene Expression Regulation, Viral[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Interferons/*metabolism[MESH] |Isoenzymes/biosynthesis/genetics[MESH] |Protein Stability[MESH] |RNA-Seq[MESH] |Receptors, Coronavirus/metabolism[MESH] |Retroelements/*genetics[MESH] |SARS-CoV-2/metabolism[MESH] |Tissue Distribution[MESH]Tissue-specific and interferon-inducible expression of nonfunctional A(epmc).pdf DeepDyve Pubget Overpricing