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10.1038/s41598-020-73955-8

http://scihub22266oqcxt.onion/10.1038/s41598-020-73955-8
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33077873!7573596!33077873
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suck abstract from ncbi


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pmid33077873      Sci+Rep 2020 ; 10 (1): 17718
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  • Reduced numbers of T cells and B cells correlates with persistent SARS-CoV-2 presence in non-severe COVID-19 patients #MMPMID33077873
  • Liu B; Han J; Cheng X; Yu L; Zhang L; Wang W; Ni L; Wei C; Huang Y; Cheng Z
  • Sci Rep 2020[Oct]; 10 (1): 17718 PMID33077873show ga
  • COVID-19 has been widely spreading. We aimed to examine adaptive immune cells in non-severe patients with persistent SARS-CoV-2 shedding. 37 non-severe patients with persistent SARS-CoV-2 presence that were transferred to Zhongnan hospital of Wuhan University were retrospectively recruited to the PP (persistently positive) group, which was further allocated to PPP group (n = 19) and PPN group (n = 18), according to their testing results after 7 days (N = negative). Epidemiological, demographic, clinical and laboratory data were collected and analyzed. Data from age- and sex-matched non-severe patients at disease onset (PA [positive on admission] patients, n = 37), and lymphocyte subpopulation measurements from matched 54 healthy subjects were extracted for comparison (HC). Compared with PA patients, PP patients had much improved laboratory findings. The absolute numbers of CD3(+) T cells, CD4(+) T cells, and NK cells were significantly higher in PP group than that in PA group, and were comparable to that in healthy controls. PPP subgroup had markedly reduced B cells and T cells compared to PPN group and healthy subjects. Finally, paired results of these lymphocyte subpopulations from 10 PPN patients demonstrated that the number of T cells and B cells significantly increased when the SARS-CoV-2 tests turned negative. Persistent SARS-CoV-2 presence in non-severe COVID-19 patients is associated with reduced numbers of adaptive immune cells. Monitoring lymphocyte subpopulations could be clinically meaningful in identifying fully recovered COVID-19 patients.
  • |Adult[MESH]
  • |B-Lymphocytes/*cytology/immunology/metabolism[MESH]
  • |Betacoronavirus/isolation & purification[MESH]
  • |CD4-Positive T-Lymphocytes/cytology/immunology/metabolism[MESH]
  • |COVID-19[MESH]
  • |Case-Control Studies[MESH]
  • |Coronavirus Infections/immunology/*pathology/virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Killer Cells, Natural/cytology/immunology/metabolism[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/immunology/*pathology/virology[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]


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