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10.1182/bloodadvances.2020002650 http://scihub22266oqcxt.onion/10.1182/bloodadvances.2020002650 33075136!7594380!33075136     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood+Adv 2020 ; 4 (20): 5035-5039 Nephropedia Template TP {{tp|p=33075136|t=2020. Impaired natural killer cell counts and cytolytic activity in patients with severe COVID-19 |pdf=|usr=}}{{33075136}} gab.com Text Impaired natural killer cell counts and cytolytic activity in patients with severe COVID-19 JO: Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=33075136 #FOAvip The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-driven coronavirus disease 2019 (COVID-19) has caused unprecedented human death and has seriously threatened the global economy. Early data suggest a surge in proinflammatory cytokines in patients with severe COVID-19, which has been associated with poor outcomes. We recently postulated that the inflammatory response in patients with severe COVID-19 disease is not inhibited by natural killer (NK) cells, resulting in a "cytokine storm." Here, we assessed the NK-cell functional activity and the associated cytokines and soluble mediators in hospitalized COVID-19 patients. Significantly impaired NK-cell counts and cytolytic activity were observed in COVID-19 patients when compared with healthy controls. Also, cytokines like interleukin 12 (IL12), IL15, and IL21 that are important for NK-cell activity were not detected systematically. Serum concentrations of soluble CD25 (sCD25)/soluble IL2 receptor alpha (sIL2-Ralpha) were significantly elevated and were inversely correlated with the percentage of NK cells. Impaired NK-cell cytolytic activity together with other laboratory trends including elevated sCD25 were consistent with a hyperinflammatory state in keeping with macrophage-activation syndrome. Our findings suggest that impaired counts and cytolytic activity of NK cells are important characteristics of severe COVID-19 and can potentially facilitate strategies for immunomodulatory therapies. Twit Text FOAVip Impaired natural killer cell counts and cytolytic activity in patients with severe COVID-19 ????Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=33075136 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33075136 #FOAvip English Wikipedia <ref>{{Cite pmid|33075136}}</ref> Impaired natural killer cell counts and cytolytic activity in patients with severe COVID-19 #MMPMID33075136 Osman M; Faridi RM; Sligl W; Shabani-Rad MT; Dharmani-Khan P; Parker A; Kalra A; Tripathi MB; Storek J; Cohen Tervaert JW; Khan FM Blood Adv 2020[Oct]; 4 (20): 5035-5039 PMID33075136show ga The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-driven coronavirus disease 2019 (COVID-19) has caused unprecedented human death and has seriously threatened the global economy. Early data suggest a surge in proinflammatory cytokines in patients with severe COVID-19, which has been associated with poor outcomes. We recently postulated that the inflammatory response in patients with severe COVID-19 disease is not inhibited by natural killer (NK) cells, resulting in a "cytokine storm." Here, we assessed the NK-cell functional activity and the associated cytokines and soluble mediators in hospitalized COVID-19 patients. Significantly impaired NK-cell counts and cytolytic activity were observed in COVID-19 patients when compared with healthy controls. Also, cytokines like interleukin 12 (IL12), IL15, and IL21 that are important for NK-cell activity were not detected systematically. Serum concentrations of soluble CD25 (sCD25)/soluble IL2 receptor alpha (sIL2-Ralpha) were significantly elevated and were inversely correlated with the percentage of NK cells. Impaired NK-cell cytolytic activity together with other laboratory trends including elevated sCD25 were consistent with a hyperinflammatory state in keeping with macrophage-activation syndrome. Our findings suggest that impaired counts and cytolytic activity of NK cells are important characteristics of severe COVID-19 and can potentially facilitate strategies for immunomodulatory therapies. |*Cytotoxicity, Immunologic[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Betacoronavirus/immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/blood/*immunology[MESH] |Female[MESH] |Humans[MESH] |Inflammation/blood/immunology[MESH] |Interleukin-2 Receptor alpha Subunit/blood/immunology[MESH] |Interleukins/blood/immunology[MESH] |Killer Cells, Natural/*immunology[MESH] |Lymphocyte Count[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*immunology[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH]Impaired natural killer cell counts and cytolytic activity in patients(epmc).pdf DeepDyve Pubget Overpricing