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10.3233/JAD-200986

http://scihub22266oqcxt.onion/10.3233/JAD-200986
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33074241!ä!33074241

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pmid33074241      J+Alzheimers+Dis 2020 ; 78 (3): 905-906
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  • Antivirals Against SARS-CoV2: Relevance to the Treatment of Alzheimer s Disease #MMPMID33074241
  • Itzhaki RF
  • J Alzheimers Dis 2020[]; 78 (3): 905-906 PMID33074241show ga
  • A recent study in vitro has shown that a sulphated polysaccharide, a type of fucoidan, has potent antiviral activity against SARS-Cov2. If the antiviral action were successful also for COVID-19 patients, it would be enormously valuable against not only acute disease but also long-term mental effects, which might include Alzheimer's disease (AD). In a trial of AD patients, the apparent success of treatment with a polysaccharide, GV971, was suggested to result from antiviral action against herpes simplex virus type 1 (HSV1) in brain, a pathogen strongly implicated in AD, and that sulphation of GV971, making it fucoidan-like, might increase its putative antiviral action. These data indicate that treatment of AD patients might be very effective using valacyclovir, a conventional antiviral, which inhibits viral replication, together with a fucoidan, which blocks virus entry into cells.
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