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10.1111/cpr.12923 http://scihub22266oqcxt.onion/10.1111/cpr.12923 33073910!7645955!33073910     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Prolif 2020 ; 53 (12): e12923 Nephropedia Template TP {{tp|p=33073910|t=2020. Detection of SARS-CoV-2 in saliva and characterization of oral symptoms in COVID-19 patients |pdf=|usr=}}{{33073910}} gab.com Text Detection of SARS-CoV-2 in saliva and characterization of oral symptoms in COVID-19 patients JO: Cell Prolif http://www.kidney.de/pget.php?&tw=1&pmid=33073910 #FOAvip OBJECTIVES: In order to provide a more comprehensive understanding of the effects of SARS-CoV-2 on oral health and possible saliva transmission, we performed RNA-seq profiles analysis from public databases and also a questionnaire survey on oral-related symptoms of COVID-19 patients. MATERIALS AND METHODS: To analyse ACE2 expression in salivary glands, bulk RNA-seq profiles from four public datasets including 31 COVID-19 patients were recruited. Saliva and oropharyngeal swabs were collected. SARS-CoV-2 nucleic acids in saliva were detected by real-time polymerase chain reaction (RT-PCR). Additionally, a questionnaire survey on various oral symptoms such as dry mouth and amblygeustia was also carried out on COVID-19 patients. RESULTS: ACE2 expression was present at detectable levels in the salivary glands. In addition, of four cases with positive detection of salivary SARS-CoV-2 nucleic acids, three (75%) were critically ill on ventilator support. Furthermore, we observed the two major oral-related symptoms, dry mouth (46.3%) and amblygeustia (47.2%), were manifested by a relatively high proportion of 108 COVID-19 patients who accepted the questionnaire survey. CONCLUSIONS: This study confirms the expression of ACE2 in the salivary glands and demonstrates the possibility of SARS-CoV-2 infection of salivary glands. Saliva may be a new source of diagnostic specimens for critically ill patients, since it can be easily collected without any invasive procedures. In addition, dry mouth and amblygeustia can be considered as initial symptoms of COVID-19 infection. Twit Text FOAVip Detection of SARS-CoV-2 in saliva and characterization of oral symptoms in COVID-19 patients ????Cell Prolif http://www.kidney.de/pget.php?&tw=1&pmid=33073910 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33073910 #FOAvip English Wikipedia <ref>{{Cite pmid|33073910}}</ref> Detection of SARS-CoV-2 in saliva and characterization of oral symptoms in COVID-19 patients #MMPMID33073910 Chen L; Zhao J; Peng J; Li X; Deng X; Geng Z; Shen Z; Guo F; Zhang Q; Jin Y; Wang L; Wang S Cell Prolif 2020[Dec]; 53 (12): e12923 PMID33073910show ga OBJECTIVES: In order to provide a more comprehensive understanding of the effects of SARS-CoV-2 on oral health and possible saliva transmission, we performed RNA-seq profiles analysis from public databases and also a questionnaire survey on oral-related symptoms of COVID-19 patients. MATERIALS AND METHODS: To analyse ACE2 expression in salivary glands, bulk RNA-seq profiles from four public datasets including 31 COVID-19 patients were recruited. Saliva and oropharyngeal swabs were collected. SARS-CoV-2 nucleic acids in saliva were detected by real-time polymerase chain reaction (RT-PCR). Additionally, a questionnaire survey on various oral symptoms such as dry mouth and amblygeustia was also carried out on COVID-19 patients. RESULTS: ACE2 expression was present at detectable levels in the salivary glands. In addition, of four cases with positive detection of salivary SARS-CoV-2 nucleic acids, three (75%) were critically ill on ventilator support. Furthermore, we observed the two major oral-related symptoms, dry mouth (46.3%) and amblygeustia (47.2%), were manifested by a relatively high proportion of 108 COVID-19 patients who accepted the questionnaire survey. CONCLUSIONS: This study confirms the expression of ACE2 in the salivary glands and demonstrates the possibility of SARS-CoV-2 infection of salivary glands. Saliva may be a new source of diagnostic specimens for critically ill patients, since it can be easily collected without any invasive procedures. In addition, dry mouth and amblygeustia can be considered as initial symptoms of COVID-19 infection. |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |COVID-19/*diagnosis[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Real-Time Polymerase Chain Reaction/methods[MESH] |SARS-CoV-2/*pathogenicity[MESH]Detection of SARS-CoV-2 in saliva and characterization of oral symptom(epmc).pdf DeepDyve Pubget Overpricing