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10.1080/22221751.2020.1838955 http://scihub22266oqcxt.onion/10.1080/22221751.2020.1838955 33073694!7655046!33073694     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Emerg+Microbes+Infect 2020 ; 9 (1): 2433-2445 Nephropedia Template TP {{tp|p=33073694|t=2020. Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection |pdf=|usr=}}{{33073694}} gab.com Text Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection JO: Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=33073694 #FOAvip Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is currently causing a worldwide pandemic with high morbidity and mortality. Development of animal models that recapitulate important aspects of coronavirus disease 2019 (COVID-19) is critical for the evaluation of vaccines and antivirals, and understanding disease pathogenesis. SARS-CoV-2 has been shown to use the same entry receptor as SARS-CoV-1, human angiotensin-converting enzyme 2 (hACE2) [1-3]. Due to amino acid differences between murine and hACE2, inbred mouse strains fail to support high titer viral replication of SARS-CoV-2 virus. Therefore, a number of transgenic and knock-in mouse models, as well as viral vector-mediated hACE2 delivery systems have been developed. Here we compared the K18-hACE2 transgenic model to adenovirus-mediated delivery of hACE2 to the mouse lung. We show that K18-hACE2 mice replicate virus to high titers in the nasal turbinates, lung and brain, with high lethality, and cytokine/chemokine production. In contrast, adenovirus-mediated delivery results in viral replication to lower titers limited to the nasal turbinates and lung, and no clinical signs of infection. The K18-hACE2 model provides a stringent model for testing vaccines and antivirals, whereas the adenovirus delivery system has the flexibility to be used across multiple genetic backgrounds and modified mouse strains. Twit Text FOAVip Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection ????Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=33073694 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33073694 #FOAvip English Wikipedia <ref>{{Cite pmid|33073694}}</ref> Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection #MMPMID33073694 Rathnasinghe R; Strohmeier S; Amanat F; Gillespie VL; Krammer F; Garcia-Sastre A; Coughlan L; Schotsaert M; Uccellini MB Emerg Microbes Infect 2020[Dec]; 9 (1): 2433-2445 PMID33073694show ga Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is currently causing a worldwide pandemic with high morbidity and mortality. Development of animal models that recapitulate important aspects of coronavirus disease 2019 (COVID-19) is critical for the evaluation of vaccines and antivirals, and understanding disease pathogenesis. SARS-CoV-2 has been shown to use the same entry receptor as SARS-CoV-1, human angiotensin-converting enzyme 2 (hACE2) [1-3]. Due to amino acid differences between murine and hACE2, inbred mouse strains fail to support high titer viral replication of SARS-CoV-2 virus. Therefore, a number of transgenic and knock-in mouse models, as well as viral vector-mediated hACE2 delivery systems have been developed. Here we compared the K18-hACE2 transgenic model to adenovirus-mediated delivery of hACE2 to the mouse lung. We show that K18-hACE2 mice replicate virus to high titers in the nasal turbinates, lung and brain, with high lethality, and cytokine/chemokine production. In contrast, adenovirus-mediated delivery results in viral replication to lower titers limited to the nasal turbinates and lung, and no clinical signs of infection. The K18-hACE2 model provides a stringent model for testing vaccines and antivirals, whereas the adenovirus delivery system has the flexibility to be used across multiple genetic backgrounds and modified mouse strains. |A549 Cells[MESH] |Adenoviridae/genetics[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus/*growth & development/metabolism[MESH] |COVID-19[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/*pathology[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Humans[MESH] |Lung/pathology/virology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |Mice, Transgenic[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*genetics[MESH] |Pneumonia, Viral/*pathology[MESH] |SARS-CoV-2[MESH] |Severe acute respiratory syndrome-related coronavirus/*growth & development/metabolism[MESH] |Vero Cells[MESH] |Virus Attachment[MESH]Comparison of transgenic and adenovirus hACE2 mouse models for SARS-Co(epmc).pdf DeepDyve Pubget Overpricing