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Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Panminerva+Med 2022 ; 64 (1): 80-95 Nephropedia Template TP
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SARS-CoV-2-related lung pathology: macroscopic and histologic features and their clinical implications #MMPMID33073555
Sanguedolce F; Zanelli M; Ascani S; Zizzo M; Tortorella S; Soriano A; Cavazza A; Sollitto F; Loizzi D
Panminerva Med 2022[Mar]; 64 (1): 80-95 PMID33073555show ga
The ongoing global Coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), has been posing challenges to proper patients' management. Lungs are the first, and often the most affected organ by SARS-CoV-2; viral infection involves and damages both epithelial and vascular compartments, sometimes leading to severe and even fatal acute respiratory distress syndrome. Histopathological findings, mainly from post-mortem examination of COVID-19 deceased patients, have been increasingly published in the last few months, helping to elucidate the sequence of events resulting in organ injury and the complex multifactorial pathogenesis of this novel disease. A multidisciplinary approach to autopsy, including light microscopy examination along with the detection of viral proteins and/or RNA in tissue samples through ancillary techniques, provided crucial information on the mechanisms underlying the often-heterogeneous clinical picture of COVID-19.