Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/eji.202048908 http://scihub22266oqcxt.onion/10.1002/eji.202048908 33073359!ä!33073359 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2020 ; 50 (12): 1998-2012 Nephropedia Template TP {{tp|p=33073359|t=2020. Divergent SARS-CoV-2-specific T- and B-cell responses in severe but not mild COVID-19 patients |pdf=|usr=}}{{33073359}} gab.com Text Divergent SARS-CoV-2-specific T- and B-cell responses in severe but not mild COVID-19 patients JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33073359 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current coronavirus disease 2019 (COVID-19) pandemic. Understanding the immune response that provides specific immunity but may also lead to immunopathology is crucial for the design of potential preventive and therapeutic strategies. Here, we characterized and quantified SARS-CoV-2-specific immune responses in patients with different clinical courses. Compared to individuals with a mild clinical presentation, CD4(+) T-cell responses were qualitatively impaired in critically ill patients. Strikingly, however, in these patients the specific IgG antibody response was remarkably strong. Furthermore, in these critically ill patients, a massive influx of circulating T cells into the lungs was observed, overwhelming the local T-cell compartment, and indicative of vascular leakage. The observed disparate T- and B-cell responses could be indicative of a deregulated immune response in critically ill COVID-19 patients. Twit Text FOAVip Divergent SARS-CoV-2-specific T- and B-cell responses in severe but not mild COVID-19 patients ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33073359 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33073359 #FOAvip English Wikipedia <ref>{{Cite pmid|33073359}}</ref> Divergent SARS-CoV-2-specific T- and B-cell responses in severe but not mild COVID-19 patients #MMPMID33073359 Oja AE; Saris A; Ghandour CA; Kragten NAM; Hogema BM; Nossent EJ; Heunks LMA; Cuvalay S; Slot E; Linty F; Swaneveld FH; Vrielink H; Vidarsson G; Rispens T; van der Schoot E; van Lier RAW; Ten Brinke A; Hombrink P Eur J Immunol 2020[Dec]; 50 (12): 1998-2012 PMID33073359show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current coronavirus disease 2019 (COVID-19) pandemic. Understanding the immune response that provides specific immunity but may also lead to immunopathology is crucial for the design of potential preventive and therapeutic strategies. Here, we characterized and quantified SARS-CoV-2-specific immune responses in patients with different clinical courses. Compared to individuals with a mild clinical presentation, CD4(+) T-cell responses were qualitatively impaired in critically ill patients. Strikingly, however, in these patients the specific IgG antibody response was remarkably strong. Furthermore, in these critically ill patients, a massive influx of circulating T cells into the lungs was observed, overwhelming the local T-cell compartment, and indicative of vascular leakage. The observed disparate T- and B-cell responses could be indicative of a deregulated immune response in critically ill COVID-19 patients. |Adult[MESH] |Aged[MESH] |Antibodies, Viral/*immunology[MESH] |B-Lymphocytes/*immunology/pathology[MESH] |CD4-Positive T-Lymphocytes/*immunology/pathology[MESH] |COVID-19/*immunology/pathology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin G/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/*immunology[MESH]Divergent SARS-CoV-2-specific T- and B-cell responses in severe but no(epmc).pdf DeepDyve Pubget Overpricing