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10.1021/acsptsci.0c00114

http://scihub22266oqcxt.onion/10.1021/acsptsci.0c00114
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33073198!7552174!33073198
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suck abstract from ncbi


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pmid33073198      ACS+Pharmacol+Transl+Sci 2020 ; 3 (5): 1027-1029
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  • Therapeutically Targeted Destabilization of the Quaternary Structure of the Spike Protein in the Dominant G614 Strain of SARS-CoV-2 #MMPMID33073198
  • Fernandez A
  • ACS Pharmacol Transl Sci 2020[Oct]; 3 (5): 1027-1029 PMID33073198show ga
  • The evolutionary change of SARS-CoV-2 is of the outmost concern. With a more stable phenotype, mutation D614G has become dominant. Its structural impact prompts the development of an antibody that destabilizes the virus quaternary structure where it is most vulnerable. Vaccine-related antigenic regions are different from the proposed epitope, hence avoiding therapeutic redundancy.
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