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10.1016/j.cophys.2020.09.015

http://scihub22266oqcxt.onion/10.1016/j.cophys.2020.09.015
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suck abstract from ncbi


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pmid33073073      Curr+Opin+Physiol 2021 ; 19 (ä): 62-72
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  • Time to get ill: the intersection of viral infections, sex, and the X chromosome #MMPMID33073073
  • Forsyth KS; Anguera MC
  • Curr Opin Physiol 2021[Feb]; 19 (ä): 62-72 PMID33073073show ga
  • Females have more robust immune responses than males, and viral infections are more severe for males. Hormones and genetic sex, namely the X chromosome, influence sex differences with immune responses. Here, we review recent findings underlying sexual dimorphism of disease susceptibility for two prevalent viral infections, influenza and SARS-CoV-2, which exhibit male-biased disease severity. Viral infections are proposed to be an initiating event for autoimmunity, which exhibits a female bias. We also review recent work elucidating the epigenetic and genetic contribution of X-Chromosome Inactivation maintenance, and X-linked gene expression, for the autoimmune disorder Systemic Lupus Erythematosus, and highlight the complex considerations required for identifying underlying hormonal and genetic contributions responsible for sex differences in immune responses.
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