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10.1016/j.waojou.2020.100476 http://scihub22266oqcxt.onion/10.1016/j.waojou.2020.100476 33072240!7546230!33072240     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33072240&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       World+Allergy+Organ+J 2020 ; 13 (11): 100476 Nephropedia Template TP {{tp|p=33072240|t=2020. Enhancing innate immunity against virus in times of COVID-19: Trying to untangle facts from fictions |pdf=|usr=}}{{33072240}} gab.com Text Enhancing innate immunity against virus in times of COVID-19: Trying to untangle facts from fictions JO: World Allergy Organ J http://www.kidney.de/pget.php?&tw=1&pmid=33072240 #FOAvip INTRODUCTION: In light of the current COVID-19 pandemic, during which the world is confronted with a new, highly contagious virus that suppresses innate immunity as one of its initial virulence mechanisms, thus escaping from first-line human defense mechanisms, enhancing innate immunity seems a good preventive strategy. METHODS: Without the intention to write an official systematic review, but more to give an overview of possible strategies, in this review article we discuss several interventions that might stimulate innate immunity and thus our defense against (viral) respiratory tract infections. Some of these interventions can also stimulate the adaptive T- and B-cell responses, but our main focus is on the innate part of immunity. We divide the reviewed interventions into: 1) lifestyle related (exercise, >7 h sleep, forest walking, meditation/mindfulness, vitamin supplementation); 2) Non-specific immune stimulants (letting fever advance, bacterial vaccines, probiotics, dialyzable leukocyte extract, pidotimod), and 3) specific vaccines with heterologous effect (BCG vaccine, mumps-measles-rubeola vaccine, etc). RESULTS: For each of these interventions we briefly comment on their definition, possible mechanisms and evidence of clinical efficacy or lack of it, especially focusing on respiratory tract infections, viral infections, and eventually a reduced mortality in severe respiratory infections in the intensive care unit. At the end, a summary table demonstrates the best trials supporting (or not) clinical evidence. CONCLUSION: Several interventions have some degree of evidence for enhancing the innate immune response and thus conveying possible benefit, but specific trials in COVID-19 should be conducted to support solid recommendations. Twit Text FOAVip Enhancing innate immunity against virus in times of COVID-19: Trying to untangle facts from fictions ????World Allergy Organ J http://www.kidney.de/pget.php?&tw=1&pmid=33072240 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33072240 #FOAvip English Wikipedia <ref>{{Cite pmid|33072240}}</ref> Enhancing innate immunity against virus in times of COVID-19: Trying to untangle facts from fictions #MMPMID33072240 Larenas-Linnemann D; Rodriguez-Perez N; Arias-Cruz A; Blandon-Vijil MV; Del Rio-Navarro BE; Estrada-Cardona A; Gereda JE; Luna-Pech JA; Navarrete-Rodriguez EM; Onuma-Takane E; Pozo-Beltran CF; Rojo-Gutierrez MI World Allergy Organ J 2020[Nov]; 13 (11): 100476 PMID33072240show ga INTRODUCTION: In light of the current COVID-19 pandemic, during which the world is confronted with a new, highly contagious virus that suppresses innate immunity as one of its initial virulence mechanisms, thus escaping from first-line human defense mechanisms, enhancing innate immunity seems a good preventive strategy. METHODS: Without the intention to write an official systematic review, but more to give an overview of possible strategies, in this review article we discuss several interventions that might stimulate innate immunity and thus our defense against (viral) respiratory tract infections. Some of these interventions can also stimulate the adaptive T- and B-cell responses, but our main focus is on the innate part of immunity. We divide the reviewed interventions into: 1) lifestyle related (exercise, >7 h sleep, forest walking, meditation/mindfulness, vitamin supplementation); 2) Non-specific immune stimulants (letting fever advance, bacterial vaccines, probiotics, dialyzable leukocyte extract, pidotimod), and 3) specific vaccines with heterologous effect (BCG vaccine, mumps-measles-rubeola vaccine, etc). RESULTS: For each of these interventions we briefly comment on their definition, possible mechanisms and evidence of clinical efficacy or lack of it, especially focusing on respiratory tract infections, viral infections, and eventually a reduced mortality in severe respiratory infections in the intensive care unit. At the end, a summary table demonstrates the best trials supporting (or not) clinical evidence. CONCLUSION: Several interventions have some degree of evidence for enhancing the innate immune response and thus conveying possible benefit, but specific trials in COVID-19 should be conducted to support solid recommendations. ?Enhancing innate immunity against virus in times of COVID-19: Trying t(epmc).pdf DeepDyve Pubget Overpricing