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10.1007/s12195-020-00658-5 http://scihub22266oqcxt.onion/10.1007/s12195-020-00658-5 33072222!7553367!33072222     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Bioeng 2021 ; 14 (2): 177-185 Nephropedia Template TP {{tp|p=33072222|t=2021. Structure-Based Design of Novel Peptidomimetics Targeting the SARS-CoV-2 Spike Protein |pdf=|usr=}}{{33072222}} gab.com Text Structure-Based Design of Novel Peptidomimetics Targeting the SARS-CoV-2 Spike Protein JO: Cell Mol Bioeng http://www.kidney.de/pget.php?&tw=1&pmid=33072222 #FOAvip PURPOSE: SARS-CoV-2 is a SARS-like novel coronavirus strain first identified in December 2019 in Wuhan, China. The virus has since spread globally, resulting in the current ongoing coronavirus disease 19 (COVID-19) pandemic. SARS-CoV-2 spike protein is a critical factor in the COVID-19 pathogenesis via interactions with the host cell angiotensin-converting enzyme 2 (ACE2) PD domain. Worldwide, numerous efforts are being made to combat COVID19. In the current study, we identified potential peptidomimetics against the SARS-CoV-2 spike protein. METHODS: We utilized the information from ACE2-SARS-CoV-2 binary interactions, and based on crucial interacting interface residues, novel peptidomimetics were designed. RESULTS: Top scoring peptidomimetics were found to bind at the ACE2 binding site of the receptor-binding domain (RBD) of SARS-CoV-2 spike protein. CONCLUSIONS: The current studies could pave the way for further investigations of these novel and potent compounds against the SARS-CoV-2. Twit Text FOAVip Structure-Based Design of Novel Peptidomimetics Targeting the SARS-CoV-2 Spike Protein ????Cell Mol Bioeng http://www.kidney.de/pget.php?&tw=1&pmid=33072222 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33072222 #FOAvip English Wikipedia <ref>{{Cite pmid|33072222}}</ref> Structure-Based Design of Novel Peptidomimetics Targeting the SARS-CoV-2 Spike Protein #MMPMID33072222 Alagumuthu M; Rajpoot S; Baig MS Cell Mol Bioeng 2021[Apr]; 14 (2): 177-185 PMID33072222show ga PURPOSE: SARS-CoV-2 is a SARS-like novel coronavirus strain first identified in December 2019 in Wuhan, China. The virus has since spread globally, resulting in the current ongoing coronavirus disease 19 (COVID-19) pandemic. SARS-CoV-2 spike protein is a critical factor in the COVID-19 pathogenesis via interactions with the host cell angiotensin-converting enzyme 2 (ACE2) PD domain. Worldwide, numerous efforts are being made to combat COVID19. In the current study, we identified potential peptidomimetics against the SARS-CoV-2 spike protein. METHODS: We utilized the information from ACE2-SARS-CoV-2 binary interactions, and based on crucial interacting interface residues, novel peptidomimetics were designed. RESULTS: Top scoring peptidomimetics were found to bind at the ACE2 binding site of the receptor-binding domain (RBD) of SARS-CoV-2 spike protein. CONCLUSIONS: The current studies could pave the way for further investigations of these novel and potent compounds against the SARS-CoV-2. äStructure-Based Design of Novel Peptidomimetics Targeting the SARS-CoV(epmc).pdf DeepDyve Pubget Overpricing