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10.3389/fimmu.2020.560381 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.560381 33072099!7538662!33072099     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 560381 Nephropedia Template TP {{tp|p=33072099|t=2020. Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology |pdf=|usr=}}{{33072099}} gab.com Text Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33072099 #FOAvip BACKGROUND: Emerging evidence indicates a potential role for monocytes in COVID-19 immunopathology. We investigated two soluble markers of monocyte activation, sCD14 and sCD163, in COVID-19 patients, with the aim of characterizing their potential role in monocyte-macrophage disease immunopathology. To the best of our knowledge, this is the first study of its kind. METHODS: Fifty-nine SARS-Cov-2 positive hospitalized patients, classified according to ICU or non-ICU admission requirement, were prospectively recruited and analyzed by ELISA for levels of sCD14 and sCD163, along with other laboratory parameters, and compared to a healthy control group. RESULTS: sCD14 and sCD163 levels were significantly higher among COVID-19 patients, independently of ICU admission requirement, compared to the control group. We found a significant correlation between sCD14 levels and other inflammatory markers, particularly Interleukin-6, in the non-ICU patients group. sCD163 showed a moderate positive correlation with the time lapsed from admission to sampling, independently of severity group. Treatment with corticoids showed an interference with sCD14 levels, whereas hydroxychloroquine and tocilizumab did not. CONCLUSIONS: Monocyte-macrophage activation markers are increased and correlate with other inflammatory markers in SARS-Cov-2 infection, in association to hospital admission. These data suggest a preponderant role for monocyte-macrophage activation in the development of immunopathology of COVID-19 patients. Twit Text FOAVip Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33072099 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33072099 #FOAvip English Wikipedia <ref>{{Cite pmid|33072099}}</ref> Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology #MMPMID33072099 Gomez-Rial J; Curras-Tuala MJ; Rivero-Calle I; Gomez-Carballa A; Cebey-Lopez M; Rodriguez-Tenreiro C; Dacosta-Urbieta A; Rivero-Velasco C; Rodriguez-Nunez N; Trastoy-Pena R; Rodriguez-Garcia J; Salas A; Martinon-Torres F Front Immunol 2020[]; 11 (ä): 560381 PMID33072099show ga BACKGROUND: Emerging evidence indicates a potential role for monocytes in COVID-19 immunopathology. We investigated two soluble markers of monocyte activation, sCD14 and sCD163, in COVID-19 patients, with the aim of characterizing their potential role in monocyte-macrophage disease immunopathology. To the best of our knowledge, this is the first study of its kind. METHODS: Fifty-nine SARS-Cov-2 positive hospitalized patients, classified according to ICU or non-ICU admission requirement, were prospectively recruited and analyzed by ELISA for levels of sCD14 and sCD163, along with other laboratory parameters, and compared to a healthy control group. RESULTS: sCD14 and sCD163 levels were significantly higher among COVID-19 patients, independently of ICU admission requirement, compared to the control group. We found a significant correlation between sCD14 levels and other inflammatory markers, particularly Interleukin-6, in the non-ICU patients group. sCD163 showed a moderate positive correlation with the time lapsed from admission to sampling, independently of severity group. Treatment with corticoids showed an interference with sCD14 levels, whereas hydroxychloroquine and tocilizumab did not. CONCLUSIONS: Monocyte-macrophage activation markers are increased and correlate with other inflammatory markers in SARS-Cov-2 infection, in association to hospital admission. These data suggest a preponderant role for monocyte-macrophage activation in the development of immunopathology of COVID-19 patients. |*Antigens, CD/blood/immunology[MESH] |*Antigens, Differentiation, Myelomonocytic/blood/immunology[MESH] |*Betacoronavirus/immunology/metabolism[MESH] |*Coronavirus Infections/blood/drug therapy/immunology/pathology[MESH] |*Lipopolysaccharide Receptors/blood/immunology[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/blood/drug therapy/immunology/pathology[MESH] |*Receptors, Cell Surface/blood/immunology[MESH] |Adrenal Cortex Hormones/administration & dosage[MESH] |Adult[MESH] |Aged[MESH] |Antibodies, Monoclonal, Humanized/administration & dosage[MESH] |COVID-19[MESH] |Female[MESH] |Humans[MESH] |Hydroxychloroquine/administration & dosage[MESH] |Intensive Care Units[MESH] |Interleukin-6/blood/immunology[MESH] |Macrophage Activation[MESH] |Macrophages/immunology/metabolism/pathology[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/immunology/pathology[MESH] |Patient Admission[MESH] |SARS-CoV-2[MESH]Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Rol(epmc).pdf DeepDyve Pubget Overpricing