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10.3389/fimmu.2020.559113 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.559113 33072098!7541917!33072098     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 559113 Nephropedia Template TP {{tp|p=33072098|t=2020. The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus Infection |pdf=|usr=}}{{33072098}} gab.com Text The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus Infection JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33072098 #FOAvip As the recent outbreak of SARS-CoV-2 has highlighted, the threat of a pandemic event from zoonotic viruses, such as the deadly influenza A/H7N9 virus subtype, continues to be a major global health concern. H7N9 virus strains appear to exhibit greater disease severity in mammalian hosts compared to natural avian hosts, though the exact mechanisms underlying this are somewhat unclear. Knowledge of the H7N9 host-pathogen interactions have mainly been constrained to natural sporadic human infections. To elucidate the cellular immune mechanisms associated with disease severity and progression, we used a ferret model to closely resemble disease outcomes in humans following influenza virus infection. Intriguingly, we observed variable disease outcomes when ferrets were inoculated with the A/Anhui/1/2013 (H7N9) strain. We observed relatively reduced antigen-presenting cell activation in lymphoid tissues which may be correlative with increased disease severity. Additionally, depletions in CD8(+) T cells were not apparent in sick animals. This study provides further insight into the ways that lymphocytes maturate and traffic in response to H7N9 infection in the ferret model. Twit Text FOAVip The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus Infection ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33072098 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33072098 #FOAvip English Wikipedia <ref>{{Cite pmid|33072098}}</ref> The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus Infection #MMPMID33072098 Horman WSJ; Nguyen THO; Kedzierska K; Butler J; Shan S; Layton R; Bingham J; Payne J; Bean AGD; Layton DS Front Immunol 2020[]; 11 (ä): 559113 PMID33072098show ga As the recent outbreak of SARS-CoV-2 has highlighted, the threat of a pandemic event from zoonotic viruses, such as the deadly influenza A/H7N9 virus subtype, continues to be a major global health concern. H7N9 virus strains appear to exhibit greater disease severity in mammalian hosts compared to natural avian hosts, though the exact mechanisms underlying this are somewhat unclear. Knowledge of the H7N9 host-pathogen interactions have mainly been constrained to natural sporadic human infections. To elucidate the cellular immune mechanisms associated with disease severity and progression, we used a ferret model to closely resemble disease outcomes in humans following influenza virus infection. Intriguingly, we observed variable disease outcomes when ferrets were inoculated with the A/Anhui/1/2013 (H7N9) strain. We observed relatively reduced antigen-presenting cell activation in lymphoid tissues which may be correlative with increased disease severity. Additionally, depletions in CD8(+) T cells were not apparent in sick animals. This study provides further insight into the ways that lymphocytes maturate and traffic in response to H7N9 infection in the ferret model. |Animals[MESH] |Antigen-Presenting Cells/*immunology/pathology[MESH] |Betacoronavirus/immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology/pathology[MESH] |COVID-19[MESH] |Coronavirus Infections/immunology[MESH] |Disease Models, Animal[MESH] |Ferrets[MESH] |Host-Pathogen Interactions/*immunology[MESH] |Humans[MESH] |Influenza A Virus, H7N9 Subtype/*physiology[MESH] |Orthomyxoviridae Infections/*immunology/pathology[MESH] |Pandemics[MESH] |Pneumonia, Viral/immunology[MESH]The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus(epmc).pdf DeepDyve Pubget Overpricing