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10.1080/17843286.2020.1834285

http://scihub22266oqcxt.onion/10.1080/17843286.2020.1834285
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33070766!ä!33070766

suck abstract from ncbi


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pmid33070766      Acta+Clin+Belg 2022 ; 77 (2): 295-300
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  • Added value of anti-SARS-CoV-2 antibody testing in a Flemish nursing home during an acute COVID-19 outbreak in April 2020 #MMPMID33070766
  • Buntinx F; Claes P; Gulikers M; Verbakel J; Jan L; Van der Elst M; Van Elslande J; Van Ranst M; Vermeersch P
  • Acta Clin Belg 2022[Apr]; 77 (2): 295-300 PMID33070766show ga
  • OBJECTIVES: To examine the added value of anti-SARS-CoV-2 antibody testing in a nursing home during an acute COVID-19 outbreak. RT-PCR is the gold standard, but can be false-negative. METHODS: 119 residents and 93 staff members were tested with RT-PCR test and/or a rapid IgM/IgG test. Of these participants, 176 had both tests, 24 only RT-PCR, and 12 only IgM/IgG in the period April 14 to 16 April 2020. RESULTS: 40 (34%) residents and 11 (13%) staff were PCR-positive. Using a rapid IgM/IgG test, 17 (17%) residents and 18 (20%) staff were positive for IgM and/or IgG (IgM/IgG). Thirty-two PCR-positive residents had an IgM/IgG test: 9 (28%), 11 (34%), and 13 (41%) were positive for IgM, IgG, and IgM/IgG. Ten PCR-positive staff had an IgM/IgG test: 3 (30%), 6 (60%), and 6 (60%) were positive for IgM, IgG, and IgM/IgG. Additional IgM/IgG tests were performed in 9 residents 11 to 14 days after the positive RT-PCR test. Of those, 7 (78%) tested positive for IgM/IgG. When retested 3 weeks later, the 2 remaining residents also tested positive. Of the 134 PCR-negative participants who had an IgM/IgG test, 15 were positive for IgM/IgG (8% of the 200 participants tested with RT-PCR). CONCLUSIONS: During an acute outbreak in a nursing home, 26% of residents and staff were PCR-positive. An additional 8% was diagnosed using IgM/IgG antibody testing. The use of RT-PCR alone as the sole diagnostic method for surveillance during an acute outbreak is insufficient to grab the full extent of the outbreak.
  • |*COVID-19/diagnosis/epidemiology[MESH]
  • |Disease Outbreaks[MESH]
  • |Humans[MESH]
  • |Immunoglobulin M[MESH]
  • |Nursing Homes[MESH]
  • |SARS-CoV-2[MESH]


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