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10.1016/j.biopha.2020.110826 http://scihub22266oqcxt.onion/10.1016/j.biopha.2020.110826 33068929!7556228!33068929     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Pharmacother 2020 ; 132 (ä): 110826 Nephropedia Template TP {{tp|p=33068929|t=2020. Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model |pdf=|usr=}}{{33068929}} gab.com Text Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model JO: Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=33068929 #FOAvip OBJECTIVE: Radiation pneumonia and fibrosis are major clinical complications of radiotherapy for thoracic tumor patients, and may significantly reduce survival and quality of life. At present, no safe and effective radiation protection measures have been approved for clinical use. Phycocyanin, a protein responsible for photosynthesis from Spirulina, has been shown to have a variety of biological activities and to be beneficial for a variety of diseases, including pulmonary fibrosis. However, the preventive and protective effects of phycocyanin on radiation-induced pulmonary fibrosis have not been studied. DESIGN: X-ray single dose irradiation was used on the chest of mice to prepare a mouse model of pulmonary fibrosis, from which the effect of phycocyanin on pulmonary histopathologic change, pulmonary fibrosis, the microbiota in lung and gut, LPS, TNF-alpha, and IL-6 at different time after irradiation were evaluated. RESULTS: Phycocyanin alleviated the radiation-induced lung injury and reduced the level of inflammatory factors. Thorax irradiation led to the disorder in microbiota of the lung and gut. The variation trend of the diversity of the two tissues was opposite, but that of the microbiota composition was similar. The phycocyanin intervention regulated the composition of the lung and gut microbiota, transformed them into normal state, and reduced the level of LPS, which significantly reduced the abundance of inflammation-related bacteria, and increased the abundance of probiotics that produce short-chain fatty acids. CONCLUSION: Phycocyanin could regulate the radiation-induced disorder in lung and gut microbiota of mice, and reduce the radiation-induced lung inflammation and fibrosis. Twit Text FOAVip Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model ????Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=33068929 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33068929 #FOAvip English Wikipedia <ref>{{Cite pmid|33068929}}</ref> Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model #MMPMID33068929 Li W; Lu L; Liu B; Qin S Biomed Pharmacother 2020[Dec]; 132 (ä): 110826 PMID33068929show ga OBJECTIVE: Radiation pneumonia and fibrosis are major clinical complications of radiotherapy for thoracic tumor patients, and may significantly reduce survival and quality of life. At present, no safe and effective radiation protection measures have been approved for clinical use. Phycocyanin, a protein responsible for photosynthesis from Spirulina, has been shown to have a variety of biological activities and to be beneficial for a variety of diseases, including pulmonary fibrosis. However, the preventive and protective effects of phycocyanin on radiation-induced pulmonary fibrosis have not been studied. DESIGN: X-ray single dose irradiation was used on the chest of mice to prepare a mouse model of pulmonary fibrosis, from which the effect of phycocyanin on pulmonary histopathologic change, pulmonary fibrosis, the microbiota in lung and gut, LPS, TNF-alpha, and IL-6 at different time after irradiation were evaluated. RESULTS: Phycocyanin alleviated the radiation-induced lung injury and reduced the level of inflammatory factors. Thorax irradiation led to the disorder in microbiota of the lung and gut. The variation trend of the diversity of the two tissues was opposite, but that of the microbiota composition was similar. The phycocyanin intervention regulated the composition of the lung and gut microbiota, transformed them into normal state, and reduced the level of LPS, which significantly reduced the abundance of inflammation-related bacteria, and increased the abundance of probiotics that produce short-chain fatty acids. CONCLUSION: Phycocyanin could regulate the radiation-induced disorder in lung and gut microbiota of mice, and reduce the radiation-induced lung inflammation and fibrosis. |Animals[MESH] |Gastrointestinal Microbiome/*drug effects/radiation effects[MESH] |Inflammation/drug therapy/etiology/microbiology[MESH] |Lipopolysaccharides[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Phycocyanin/isolation & purification/*pharmacology[MESH] |Pulmonary Fibrosis/etiology/microbiology/*prevention & control[MESH] |Radiation Injuries, Experimental/microbiology/prevention & control[MESH] |Radiation Pneumonitis/microbiology/*prevention & control[MESH]Effects of phycocyanin on pulmonary and gut microbiota in a radiation-(epmc).pdf DeepDyve Pubget Overpricing