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10.1016/j.intimp.2020.107082 http://scihub22266oqcxt.onion/10.1016/j.intimp.2020.107082 33068865!7547582!33068865     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+Immunopharmacol 2020 ; 89 (Pt B): 107082 Nephropedia Template TP {{tp|p=33068865|t=2020. Recent findings on the Coronavirus disease 2019 (COVID-19); immunopathogenesis and immunotherapeutics |pdf=|usr=}}{{33068865}} gab.com Text Recent findings on the Coronavirus disease 2019 (COVID-19); immunopathogenesis and immunotherapeutics JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33068865 #FOAvip Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) is responsible for recent ongoing public health emergency in the world. Sharing structural and behavioral similarities with its ancestors [SARS and Middle East Respiratory Syndrome (MERS)], SARS-CoV-2 has lower fatality but faster transmission. We have gone through a long path to recognize SARS and MERS, therefore our knowledge regarding SARS-CoV-2 is not raw. Various responses of the immune system account for the wide spectrum of clinical manifestations in Coronavirus disease-2019 (COVID-19). Given the innate immune response as the front line of defense, it is immediately activated after the virus entry. Consequently, adaptive immune response is activated to eradicate the virus. However, this does not occur in every case and immune response is the main culprit causing the pathological manifestations of COVID-19. Lethal forms of the disease are correlated with inefficient and/or insufficient immune responses associated with cytokine storm. Current therapeutic approach for COVID-19 is in favor of suppressing extreme inflammatory responses, while maintaining the immune system alert and responsive against the virus. This could be contributing along with administration of antiviral drugs in such patients. Furthermore, supplementation with different compounds, such as vitamin D, has been tested to modulate the immune system responses. A thorough understanding of chronological events in COVID-19 contributing to the development of a highly efficient treatment has not figured out yet. This review focuses on the virus-immune system interaction as well as currently available and potential therapeutic approaches targeting immune system in the treatment of COVID-19 patients. Twit Text FOAVip Recent findings on the Coronavirus disease 2019 (COVID-19); immunopathogenesis and immunotherapeutics ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33068865 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33068865 #FOAvip English Wikipedia <ref>{{Cite pmid|33068865}}</ref> Recent findings on the Coronavirus disease 2019 (COVID-19); immunopathogenesis and immunotherapeutics #MMPMID33068865 Ebrahimi N; Aslani S; Babaie F; Hemmatzadeh M; Hosseinzadeh R; Joneidi Z; Mehdizadeh Tourzani Z; Pakravan N; Mohammadi H Int Immunopharmacol 2020[Dec]; 89 (Pt B): 107082 PMID33068865show ga Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) is responsible for recent ongoing public health emergency in the world. Sharing structural and behavioral similarities with its ancestors [SARS and Middle East Respiratory Syndrome (MERS)], SARS-CoV-2 has lower fatality but faster transmission. We have gone through a long path to recognize SARS and MERS, therefore our knowledge regarding SARS-CoV-2 is not raw. Various responses of the immune system account for the wide spectrum of clinical manifestations in Coronavirus disease-2019 (COVID-19). Given the innate immune response as the front line of defense, it is immediately activated after the virus entry. Consequently, adaptive immune response is activated to eradicate the virus. However, this does not occur in every case and immune response is the main culprit causing the pathological manifestations of COVID-19. Lethal forms of the disease are correlated with inefficient and/or insufficient immune responses associated with cytokine storm. Current therapeutic approach for COVID-19 is in favor of suppressing extreme inflammatory responses, while maintaining the immune system alert and responsive against the virus. This could be contributing along with administration of antiviral drugs in such patients. Furthermore, supplementation with different compounds, such as vitamin D, has been tested to modulate the immune system responses. A thorough understanding of chronological events in COVID-19 contributing to the development of a highly efficient treatment has not figured out yet. This review focuses on the virus-immune system interaction as well as currently available and potential therapeutic approaches targeting immune system in the treatment of COVID-19 patients. |*Immunotherapy[MESH] |*SARS-CoV-2[MESH] |Adaptive Immunity[MESH] |Angiotensin-Converting Enzyme 2/physiology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/etiology/*immunology[MESH] |Humans[MESH] |Immune System/drug effects[MESH] |Immunity, Innate[MESH] |Virus Internalization[MESH]Recent findings on the Coronavirus disease 2019 (COVID-19); immunopath(epmc).pdf DeepDyve Pubget Overpricing