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10.1016/j.ejphar.2020.173621 http://scihub22266oqcxt.onion/10.1016/j.ejphar.2020.173621 33068588!7554476!33068588     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Pharmacol 2021 ; 890 (ä): 173621 Nephropedia Template TP {{tp|p=33068588|t=2021. Perspectives on mechanistic implications of ROS inducers for targeting viral infections |pdf=|usr=}}{{33068588}} gab.com Text Perspectives on mechanistic implications of ROS inducers for targeting viral infections JO: Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33068588 #FOAvip In this perspective, we propose to leverage reactive oxygen species (ROS) induction as a potential therapeutic measure against viral infections. Our rationale for targeting RNA viral infections by pro-oxidants is routed on the mechanistic hypothesis that ROS based treatment paradigm could impair RNA integrity faster than the other macromolecules. Though antiviral drugs with antioxidant properties confer potential abilities for preventing viral entry, those with pro-oxidant properties could induce the degradation of nascent viral RNA within the host cells, as RNAs are highly prone to ROS mediated degradation than DNA/proteins. We have previously established that Plumbagin is a highly potent ROS inducer, which acts through shifting of the host redox potential. Besides, it has been reported that Plumbagin treatment has the potential for interrupting viral RNA replication within the host cells. Since the on-going Corona Virus Disease - 2019 (COVID-19) global pandemic mediated by Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) exhibits high infectivity, the development of appropriate antiviral therapeutic strategies remains to be an urgent unmet race against time. Therefore, additional experimental validation is warranted to determine the appropriateness of repurposable drug candidates, possibly ROS inducers, for fighting the pandemic which could lead to saving many lives from being lost to COVID-19. Twit Text FOAVip Perspectives on mechanistic implications of ROS inducers for targeting viral infections ????Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33068588 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33068588 #FOAvip English Wikipedia <ref>{{Cite pmid|33068588}}</ref> Perspectives on mechanistic implications of ROS inducers for targeting viral infections #MMPMID33068588 Nadhan R; Patra D; Krishnan N; Rajan A; Gopala S; Ravi D; Srinivas P Eur J Pharmacol 2021[Jan]; 890 (ä): 173621 PMID33068588show ga In this perspective, we propose to leverage reactive oxygen species (ROS) induction as a potential therapeutic measure against viral infections. Our rationale for targeting RNA viral infections by pro-oxidants is routed on the mechanistic hypothesis that ROS based treatment paradigm could impair RNA integrity faster than the other macromolecules. Though antiviral drugs with antioxidant properties confer potential abilities for preventing viral entry, those with pro-oxidant properties could induce the degradation of nascent viral RNA within the host cells, as RNAs are highly prone to ROS mediated degradation than DNA/proteins. We have previously established that Plumbagin is a highly potent ROS inducer, which acts through shifting of the host redox potential. Besides, it has been reported that Plumbagin treatment has the potential for interrupting viral RNA replication within the host cells. Since the on-going Corona Virus Disease - 2019 (COVID-19) global pandemic mediated by Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) exhibits high infectivity, the development of appropriate antiviral therapeutic strategies remains to be an urgent unmet race against time. Therefore, additional experimental validation is warranted to determine the appropriateness of repurposable drug candidates, possibly ROS inducers, for fighting the pandemic which could lead to saving many lives from being lost to COVID-19. |*COVID-19 Drug Treatment[MESH] |*SARS-CoV-2[MESH] |Animals[MESH] |Antiviral Agents/*therapeutic use[MESH] |COVID-19/metabolism/virology[MESH] |Humans[MESH] |Naphthoquinones/*therapeutic use[MESH] |Pandemics[MESH] |RNA, Viral[MESH] |Reactive Oxygen Species/*metabolism[MESH]Perspectives on mechanistic implications of ROS inducers for targeting(epmc).pdf DeepDyve Pubget Overpricing