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10.1093/nar/gkaa864 http://scihub22266oqcxt.onion/10.1093/nar/gkaa864 33068416!7672441!33068416     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 2020 ; 48 (20): 11270-11283 Nephropedia Template TP {{tp|p=33068416|t=2020. Structural analysis of SARS-CoV-2 genome and predictions of the human interactome |pdf=|usr=}}{{33068416}} gab.com Text Structural analysis of SARS-CoV-2 genome and predictions of the human interactome JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=33068416 #FOAvip Specific elements of viral genomes regulate interactions within host cells. Here, we calculated the secondary structure content of >2000 coronaviruses and computed >100 000 human protein interactions with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The genomic regions display different degrees of conservation. SARS-CoV-2 domain encompassing nucleotides 22 500-23 000 is conserved both at the sequence and structural level. The regions upstream and downstream, however, vary significantly. This part of the viral sequence codes for the Spike S protein that interacts with the human receptor angiotensin-converting enzyme 2 (ACE2). Thus, variability of Spike S is connected to different levels of viral entry in human cells within the population. Our predictions indicate that the 5' end of SARS-CoV-2 is highly structured and interacts with several human proteins. The binding proteins are involved in viral RNA processing, include double-stranded RNA specific editases and ATP-dependent RNA-helicases and have strong propensity to form stress granules and phase-separated assemblies. We propose that these proteins, also implicated in viral infections such as HIV, are selectively recruited by SARS-CoV-2 genome to alter transcriptional and post-transcriptional regulation of host cells and to promote viral replication. Twit Text FOAVip Structural analysis of SARS-CoV-2 genome and predictions of the human interactome ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=33068416 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33068416 #FOAvip English Wikipedia <ref>{{Cite pmid|33068416}}</ref> Structural analysis of SARS-CoV-2 genome and predictions of the human interactome #MMPMID33068416 Vandelli A; Monti M; Milanetti E; Armaos A; Rupert J; Zacco E; Bechara E; Delli Ponti R; Tartaglia GG Nucleic Acids Res 2020[Nov]; 48 (20): 11270-11283 PMID33068416show ga Specific elements of viral genomes regulate interactions within host cells. Here, we calculated the secondary structure content of >2000 coronaviruses and computed >100 000 human protein interactions with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The genomic regions display different degrees of conservation. SARS-CoV-2 domain encompassing nucleotides 22 500-23 000 is conserved both at the sequence and structural level. The regions upstream and downstream, however, vary significantly. This part of the viral sequence codes for the Spike S protein that interacts with the human receptor angiotensin-converting enzyme 2 (ACE2). Thus, variability of Spike S is connected to different levels of viral entry in human cells within the population. Our predictions indicate that the 5' end of SARS-CoV-2 is highly structured and interacts with several human proteins. The binding proteins are involved in viral RNA processing, include double-stranded RNA specific editases and ATP-dependent RNA-helicases and have strong propensity to form stress granules and phase-separated assemblies. We propose that these proteins, also implicated in viral infections such as HIV, are selectively recruited by SARS-CoV-2 genome to alter transcriptional and post-transcriptional regulation of host cells and to promote viral replication. |*Genome, Viral[MESH] |*Protein Interaction Maps[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |COVID-19/virology[MESH] |Humans[MESH] |Protein Binding[MESH] |SARS-CoV-2/*genetics/pathogenicity/physiology[MESH] |Spike Glycoprotein, Coronavirus/chemistry/genetics/metabolism[MESH] |Virulence/genetics[MESH] |Virus Internalization[MESH]Structural analysis of SARS-CoV-2 genome and predictions of the human (epmc).pdf DeepDyve Pubget Overpricing