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10.1186/s13054-020-03323-5 http://scihub22266oqcxt.onion/10.1186/s13054-020-03323-5 33066801!7562762!33066801     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Crit+Care 2020 ; 24 (1): 610 Nephropedia Template TP {{tp|p=33066801|t=2020. SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients |pdf=|usr=}}{{33066801}} gab.com Text SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients JO: Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=33066801 #FOAvip BACKGROUND: Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically ill COVID-19 patients. METHODS: We conducted a binational study merging prospectively collected data from two COVID-19 reference centers in France and Switzerland. First, we described the viral shedding duration (i.e., time to negativity) in LRT samples. Second, we analyzed viral load in LRT samples. Third, we assessed the association between viral presence in LRT and mortality using mixed-effect logistic models for clustered data adjusting for the time between symptoms' onset and date of sampling. RESULTS: From March to May 2020, 267 LRT samples were performed in 90 patients from both centers. The median time to negativity was 29 (IQR 23; 34) days. Prolonged viral shedding was not associated with age, gender, cardiac comorbidities, diabetes, immunosuppression, corticosteroids use, or antiviral therapy. The LRT viral load tended to be higher in non-survivors. This difference was statistically significant after adjusting for the time interval between onset of symptoms and date of sampling (OR 3.78, 95% CI 1.13-12.64, p = 0.03). CONCLUSIONS: The viral shedding in LRT lasted almost 30 days in median in critically ill patients, and the viral load in the LRT was associated with the 6-week mortality. Twit Text FOAVip SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients ????Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=33066801 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33066801 #FOAvip English Wikipedia <ref>{{Cite pmid|33066801}}</ref> SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients #MMPMID33066801 Buetti N; Wicky PH; Le Hingrat Q; Ruckly S; Mazzuchelli T; Loiodice A; Trimboli P; Forni Ogna V; de Montmollin E; Bernasconi E; Visseaux B; Timsit JF Crit Care 2020[Oct]; 24 (1): 610 PMID33066801show ga BACKGROUND: Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically ill COVID-19 patients. METHODS: We conducted a binational study merging prospectively collected data from two COVID-19 reference centers in France and Switzerland. First, we described the viral shedding duration (i.e., time to negativity) in LRT samples. Second, we analyzed viral load in LRT samples. Third, we assessed the association between viral presence in LRT and mortality using mixed-effect logistic models for clustered data adjusting for the time between symptoms' onset and date of sampling. RESULTS: From March to May 2020, 267 LRT samples were performed in 90 patients from both centers. The median time to negativity was 29 (IQR 23; 34) days. Prolonged viral shedding was not associated with age, gender, cardiac comorbidities, diabetes, immunosuppression, corticosteroids use, or antiviral therapy. The LRT viral load tended to be higher in non-survivors. This difference was statistically significant after adjusting for the time interval between onset of symptoms and date of sampling (OR 3.78, 95% CI 1.13-12.64, p = 0.03). CONCLUSIONS: The viral shedding in LRT lasted almost 30 days in median in critically ill patients, and the viral load in the LRT was associated with the 6-week mortality. |Aged[MESH] |Betacoronavirus/*isolation & purification[MESH] |COVID-19[MESH] |Coronavirus Infections/*diagnosis/mortality[MESH] |Critical Illness/mortality[MESH] |Female[MESH] |France/epidemiology[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*diagnosis/mortality[MESH] |Prospective Studies[MESH] |Respiration, Artificial[MESH] |Respiratory Distress Syndrome/*therapy/*virology[MESH] |Respiratory System/*virology[MESH] |SARS-CoV-2[MESH] |Switzerland/epidemiology[MESH] |Viral Load[MESH]SARS-CoV-2 detection in the lower respiratory tract of invasively vent(epmc).pdf DeepDyve Pubget Overpricing