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10.1097/MCP.0000000000000743 http://scihub22266oqcxt.onion/10.1097/MCP.0000000000000743 33065600!ä!33065600 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Pulm+Med 2021 ; 27 (1): 54-60 Nephropedia Template TP {{tp|p=33065600|t=2021. Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases |pdf=|usr=}}{{33065600}} gab.com Text Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases JO: Curr Opin Pulm Med http://www.kidney.de/pget.php?&tw=1&pmid=33065600 #FOAvip PURPOSE OF REVIEW: Matrix metalloproteinases (MMPs) are a family of over 20 zinc-dependent proteases with different biological and pathological activities, and many have been implicated in several diseases. Although nonselective MMP inhibitors are known to induce serious side-effects, targeting individual MMPs may offer a safer therapeutic potential for several diseases. Hence, we provide a concise overview on MMP-12, given its association with pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, and other progressive pulmonary fibrosis (PPF), which may also occur in coronavirus disease 2019. RECENT FINDINGS: In asthma, COPD, and PPF, increased MMP-12 levels have been associated with inflammation and/or structural changes within the lungs and negatively correlated with functional parameters. Increased pulmonary MMP-12 levels and MMP-12 gene expression have been related to disease severity in asthma and COPD. Targeting MMP-12 showed potential in animal models of pulmonary diseases but human data are still very scarce. SUMMARY: Although there may be a potential role of MMP-12 in asthma, COPD and PPF, several pathophysiological aspects await elucidation. Targeting MMP-12 may provide further insights into MMP-12 related mechanisms and how this translates into clinical outcomes; this warrants further research. Twit Text FOAVip Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases ????Curr Opin Pulm Med http://www.kidney.de/pget.php?&tw=1&pmid=33065600 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33065600 #FOAvip English Wikipedia <ref>{{Cite pmid|33065600}}</ref> Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases #MMPMID33065600 Abd-Elaziz K; Jesenak M; Vasakova M; Diamant Z Curr Opin Pulm Med 2021[Jan]; 27 (1): 54-60 PMID33065600show ga PURPOSE OF REVIEW: Matrix metalloproteinases (MMPs) are a family of over 20 zinc-dependent proteases with different biological and pathological activities, and many have been implicated in several diseases. Although nonselective MMP inhibitors are known to induce serious side-effects, targeting individual MMPs may offer a safer therapeutic potential for several diseases. Hence, we provide a concise overview on MMP-12, given its association with pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, and other progressive pulmonary fibrosis (PPF), which may also occur in coronavirus disease 2019. RECENT FINDINGS: In asthma, COPD, and PPF, increased MMP-12 levels have been associated with inflammation and/or structural changes within the lungs and negatively correlated with functional parameters. Increased pulmonary MMP-12 levels and MMP-12 gene expression have been related to disease severity in asthma and COPD. Targeting MMP-12 showed potential in animal models of pulmonary diseases but human data are still very scarce. SUMMARY: Although there may be a potential role of MMP-12 in asthma, COPD and PPF, several pathophysiological aspects await elucidation. Targeting MMP-12 may provide further insights into MMP-12 related mechanisms and how this translates into clinical outcomes; this warrants further research. |Animals[MESH] |Asthma/drug therapy/*enzymology/etiology/physiopathology[MESH] |Biomarkers/metabolism[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*enzymology/etiology/physiopathology[MESH] |Humans[MESH] |Idiopathic Pulmonary Fibrosis/drug therapy/*enzymology/etiology/physiopathology[MESH] |Matrix Metalloproteinase 12/*metabolism[MESH] |Matrix Metalloproteinase Inhibitors/therapeutic use[MESH]Revisiting matrix metalloproteinase 12: its role in pathophysiology of(epmc).pdf DeepDyve Pubget Overpricing