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10.1016/j.cell.2020.10.005 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.10.005 33065030!7546181!33065030     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 183 (5): 1354-1366.e13 Nephropedia Template TP {{tp|p=33065030|t=2020. Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques |pdf=|usr=}}{{33065030}} gab.com Text Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33065030 #FOAvip The COVID-19 pandemic has led to extensive morbidity and mortality throughout the world. Clinical features that drive SARS-CoV-2 pathogenesis in humans include inflammation and thrombosis, but the mechanistic details underlying these processes remain to be determined. In this study, we demonstrate endothelial disruption and vascular thrombosis in histopathologic sections of lungs from both humans and rhesus macaques infected with SARS-CoV-2. To define key molecular pathways associated with SARS-CoV-2 pathogenesis in macaques, we performed transcriptomic analyses of bronchoalveolar lavage and peripheral blood and proteomic analyses of serum. We observed macrophage infiltrates in lung and upregulation of macrophage, complement, platelet activation, thrombosis, and proinflammatory markers, including C-reactive protein, MX1, IL-6, IL-1, IL-8, TNFalpha, and NF-kappaB. These results suggest a model in which critical interactions between inflammatory and thrombosis pathways lead to SARS-CoV-2-induced vascular disease. Our findings suggest potential therapeutic targets for COVID-19. Twit Text FOAVip Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33065030 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33065030 #FOAvip English Wikipedia <ref>{{Cite pmid|33065030}}</ref> Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques #MMPMID33065030 Aid M; Busman-Sahay K; Vidal SJ; Maliga Z; Bondoc S; Starke C; Terry M; Jacobson CA; Wrijil L; Ducat S; Brook OR; Miller AD; Porto M; Pellegrini KL; Pino M; Hoang TN; Chandrashekar A; Patel S; Stephenson K; Bosinger SE; Andersen H; Lewis MG; Hecht JL; Sorger PK; Martinot AJ; Estes JD; Barouch DH Cell 2020[Nov]; 183 (5): 1354-1366.e13 PMID33065030show ga The COVID-19 pandemic has led to extensive morbidity and mortality throughout the world. Clinical features that drive SARS-CoV-2 pathogenesis in humans include inflammation and thrombosis, but the mechanistic details underlying these processes remain to be determined. In this study, we demonstrate endothelial disruption and vascular thrombosis in histopathologic sections of lungs from both humans and rhesus macaques infected with SARS-CoV-2. To define key molecular pathways associated with SARS-CoV-2 pathogenesis in macaques, we performed transcriptomic analyses of bronchoalveolar lavage and peripheral blood and proteomic analyses of serum. We observed macrophage infiltrates in lung and upregulation of macrophage, complement, platelet activation, thrombosis, and proinflammatory markers, including C-reactive protein, MX1, IL-6, IL-1, IL-8, TNFalpha, and NF-kappaB. These results suggest a model in which critical interactions between inflammatory and thrombosis pathways lead to SARS-CoV-2-induced vascular disease. Our findings suggest potential therapeutic targets for COVID-19. |Aged, 80 and over[MESH] |Animals[MESH] |Bronchoalveolar Lavage[MESH] |C-Reactive Protein/analysis[MESH] |COVID-19/blood/*complications/*immunology/pathology[MESH] |Complement Activation[MESH] |Cytokines/blood[MESH] |Female[MESH] |Humans[MESH] |Inflammation/blood/immunology/virology[MESH] |Lung/pathology[MESH] |Macaca mulatta[MESH] |Macrophages/immunology[MESH] |Male[MESH] |Platelet Activation[MESH] |SARS-CoV-2/*genetics[MESH] |Thrombosis/blood/*complications/pathology[MESH] |Transcriptome[MESH]Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques(epmc).pdf DeepDyve Pubget Overpricing