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10.1107/S2052252520012944 http://scihub22266oqcxt.onion/10.1107/S2052252520012944 33063792!7553145!33063792     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       IUCrJ 2020 ; 7 (Pt 6): 1048-58 Nephropedia Template TP {{tp|p=33063792|t=2020. Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy |pdf=|usr=}}{{33063792}} gab.com Text Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy JO: IUCrJ http://www.kidney.de/pget.php?&tw=1&pmid=33063792 #FOAvip Dexamethasone, a widely used corticosteroid, has recently been reported as the first drug to increase the survival chances of patients with severe COVID-19. Therapeutic agents, including dexamethasone, are mostly transported through the body by binding to serum albumin. Here, the first structure of serum albumin in complex with dexamethasone is reported. Dexamethasone binds to drug site 7, which is also the binding site for commonly used nonsteroidal anti-inflammatory drugs and testosterone, suggesting potentially problematic binding competition. This study bridges structural findings with an analysis of publicly available clinical data from Wuhan and suggests that an adjustment of the dexamethasone regimen should be further investigated as a strategy for patients affected by two major COVID-19 risk factors: low albumin levels and diabetes. Twit Text FOAVip Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy ????IUCrJ http://www.kidney.de/pget.php?&tw=1&pmid=33063792 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33063792 #FOAvip English Wikipedia <ref>{{Cite pmid|33063792}}</ref> Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy #MMPMID33063792 Shabalin IG; Czub MP; Majorek KA; Brzezinski D; Grabowski M; Cooper DR; Panasiuk M; Chruszcz M; Minor W IUCrJ 2020[Sep]; 7 (Pt 6): 1048-58 PMID33063792show ga Dexamethasone, a widely used corticosteroid, has recently been reported as the first drug to increase the survival chances of patients with severe COVID-19. Therapeutic agents, including dexamethasone, are mostly transported through the body by binding to serum albumin. Here, the first structure of serum albumin in complex with dexamethasone is reported. Dexamethasone binds to drug site 7, which is also the binding site for commonly used nonsteroidal anti-inflammatory drugs and testosterone, suggesting potentially problematic binding competition. This study bridges structural findings with an analysis of publicly available clinical data from Wuhan and suggests that an adjustment of the dexamethasone regimen should be further investigated as a strategy for patients affected by two major COVID-19 risk factors: low albumin levels and diabetes. äMolecular determinants of vascular transport of dexamethasone in COVID(epmc).pdf DeepDyve Pubget Overpricing