Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1107/S2052252520012725 http://scihub22266oqcxt.onion/10.1107/S2052252520012725 33063791!7553147!33063791     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       IUCrJ 2020 ; 7 (Pt 6): 1059-69 Nephropedia Template TP {{tp|p=33063791|t=2020. Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures |pdf=|usr=}}{{33063791}} gab.com Text Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures JO: IUCrJ http://www.kidney.de/pget.php?&tw=1&pmid=33063791 #FOAvip Using a new consensus-based image-processing approach together with principal component analysis, the flexibility and conformational dynamics of the SARS-CoV-2 spike in the prefusion state have been analysed. These studies revealed concerted motions involving the receptor-binding domain (RBD), N-terminal domain, and subdomains 1 and 2 around the previously characterized 1-RBD-up state, which have been modeled as elastic deformations. It is shown that in this data set there are not well defined, stable spike conformations, but virtually a continuum of states. An ensemble map was obtained with minimum bias, from which the extremes of the change along the direction of maximal variance were modeled by flexible fitting. The results provide a warning of the potential image-processing classification instability of these complicated data sets, which has a direct impact on the interpretability of the results. Twit Text FOAVip Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures ????IUCrJ http://www.kidney.de/pget.php?&tw=1&pmid=33063791 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33063791 #FOAvip English Wikipedia <ref>{{Cite pmid|33063791}}</ref> Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures #MMPMID33063791 Melero R; Sorzano COS; Foster B; Vilas JL; Martinez M; Marabini R; Ramirez-Aportela E; Sanchez-Garcia R; Herreros D; Del Cano L; Losana P; Fonseca-Reyna YC; Conesa P; Wrapp D; Chacon P; McLellan JS; Tagare HD; Carazo JM IUCrJ 2020[Sep]; 7 (Pt 6): 1059-69 PMID33063791show ga Using a new consensus-based image-processing approach together with principal component analysis, the flexibility and conformational dynamics of the SARS-CoV-2 spike in the prefusion state have been analysed. These studies revealed concerted motions involving the receptor-binding domain (RBD), N-terminal domain, and subdomains 1 and 2 around the previously characterized 1-RBD-up state, which have been modeled as elastic deformations. It is shown that in this data set there are not well defined, stable spike conformations, but virtually a continuum of states. An ensemble map was obtained with minimum bias, from which the extremes of the change along the direction of maximal variance were modeled by flexible fitting. The results provide a warning of the potential image-processing classification instability of these complicated data sets, which has a direct impact on the interpretability of the results. äContinuous flexibility analysis of SARS-CoV-2 spike prefusion structur(epmc).pdf DeepDyve Pubget Overpricing