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suck abstract from ncbi


10.1021/acsptsci.0c00097

http://scihub22266oqcxt.onion/10.1021/acsptsci.0c00097
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33062955!7447076!33062955
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suck abstract from ncbi

pmid33062955      ACS+Pharmacol+Transl+Sci 2020 ; 3 (5): 1020-1022
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  • Dipeptidyl Peptidase-4: A Potential Therapeutic Target in Diabetic Kidney Disease with SARS-CoV-2 Infection #MMPMID33062955
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  • ACS Pharmacol Transl Sci 2020[Oct]; 3 (5): 1020-1022 PMID33062955show ga
  • Dipeptidyl peptidase-4 (DPP-4) is expressed ubiquitously in many tissues, including kidney, respiratory tract, and immune cells. Human DPP-4 has been identified as a functional receptor for the spike glycoprotein of the Middle East respiratory syndrome coronavirus. A large interface has been predicted in the docking of DPP-4/SARS-CoV-2 spike protein. Globally, 40% of diabetic patients develop diabetic kidney disease (DKD), a leading cause of end-stage renal disease. DPP-4 inhibitors possess anti-inflammatory properties which suggest their potential implication in DKD and SARS-CoV-2 immunopathogenesis.
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