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10.1021/acsptsci.0c00093 http://scihub22266oqcxt.onion/10.1021/acsptsci.0c00093 33062954!7409920!33062954     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Pharmacol+Transl+Sci 2020 ; 3 (5): 1017-1019 Nephropedia Template TP {{tp|p=33062954|t=2020. Can Papain-like Protease Inhibitors Halt SARS-CoV-2 Replication?|pdf=|usr=}}{{33062954}} gab.com Text Can Papain-like Protease Inhibitors Halt SARS-CoV-2 Replication JO: ACS Pharmacol Transl Sci http://www.kidney.de/pget.php?&tw=1&pmid=33062954 #FOAvip SARS-CoV-2 encoded papain-like protease (PLpro) harbors a labile Zn site (Cys(189)-X-X-Cys(192)-X (n) -Cys(224)-X-Cys(226)) and a classic catalytic site (Cys(111)-His(272)-Asp(286)), which play key roles for viral replication and hence represent promising drug targets. In this Viewpoint, both sulfur-based drugs and peptides-based inhibitors may block Cys residues in the catalytic and/or Zn site of CoV-2-PLpro, leading to dysfunction of CoV-2-PLpro and thereby halting viral replication. Twit Text FOAVip Can Papain-like Protease Inhibitors Halt SARS-CoV-2 Replication ????ACS Pharmacol Transl Sci http://www.kidney.de/pget.php?&tw=1&pmid=33062954 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33062954 #FOAvip English Wikipedia <ref>{{Cite pmid|33062954}}</ref> Can Papain-like Protease Inhibitors Halt SARS-CoV-2 Replication? #MMPMID33062954 Maiti BK ACS Pharmacol Transl Sci 2020[Oct]; 3 (5): 1017-1019 PMID33062954show ga SARS-CoV-2 encoded papain-like protease (PLpro) harbors a labile Zn site (Cys(189)-X-X-Cys(192)-X (n) -Cys(224)-X-Cys(226)) and a classic catalytic site (Cys(111)-His(272)-Asp(286)), which play key roles for viral replication and hence represent promising drug targets. In this Viewpoint, both sulfur-based drugs and peptides-based inhibitors may block Cys residues in the catalytic and/or Zn site of CoV-2-PLpro, leading to dysfunction of CoV-2-PLpro and thereby halting viral replication. äCan Papain-like Protease Inhibitors Halt SARS-CoV-2 Replication?(epmc).pdf DeepDyve Pubget Overpricing