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10.1038/s41423-020-00557-9

http://scihub22266oqcxt.onion/10.1038/s41423-020-00557-9
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suck abstract from ncbi


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pmid33060840      Cell+Mol+Immunol 2021 ; 18 (3): 604-612
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  • Unique immunological profile in patients with COVID-19 #MMPMID33060840
  • Varchetta S; Mele D; Oliviero B; Mantovani S; Ludovisi S; Cerino A; Bruno R; Castelli A; Mosconi M; Vecchia M; Roda S; Sachs M; Klersy C; Mondelli MU
  • Cell Mol Immunol 2021[Mar]; 18 (3): 604-612 PMID33060840show ga
  • The relationship between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and host immunity is poorly understood. We performed an extensive analysis of immune responses in 32 patients with severe COVID-19, some of whom succumbed. A control population of healthy subjects was included. Patients with COVID-19 had an altered distribution of peripheral blood lymphocytes, with an increased proportion of mature natural killer (NK) cells and low T-cell numbers. NK cells and CD8(+) T cells overexpressed T-cell immunoglobulin and mucin domain-3 (TIM-3) and CD69. NK cell exhaustion was attested by increased frequencies of programmed cell death protein 1 (PD-1) positive cells and reduced frequencies of natural killer group 2 member D (NKG2D)-, DNAX accessory molecule-1 (DNAM-1)- and sialic acid-binding Ig-like lectin 7 (Siglec-7)-expressing NK cells, associated with a reduced ability to secrete interferon (IFN)gamma. Patients with poor outcome showed a contraction of immature CD56(bright) and an expansion of mature CD57(+) FcepsilonRIgamma(neg) adaptive NK cells compared to survivors. Increased serum levels of IL-6 were also more frequently identified in deceased patients compared to survivors. Of note, monocytes secreted abundant quantities of IL-6, IL-8, and IL-1beta which persisted at lower levels several weeks after recovery with concomitant normalization of CD69, PD-1 and TIM-3 expression and restoration of CD8(+) T cell numbers. A hyperactivated/exhausted immune response dominate in severe SARS-CoV-2 infection, probably driven by an uncontrolled secretion of inflammatory cytokines by monocytes. These findings unveil a unique immunological profile in COVID-19 patients that will help to design effective stage-specific treatments for this potentially deadly disease.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antigens, Differentiation/*immunology[MESH]
  • |CD8-Positive T-Lymphocytes/*immunology/pathology[MESH]
  • |COVID-19/*immunology/pathology[MESH]
  • |Cytokines/*immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Killer Cells, Natural/*immunology/pathology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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