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10.1097/ICL.0000000000000752

http://scihub22266oqcxt.onion/10.1097/ICL.0000000000000752
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33060413!ä!33060413

suck abstract from ncbi


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pmid33060413      Eye+Contact+Lens 2021 ; 47 (4): 168-173
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  • Ocular Surface and Conjunctival Cytology Findings in Patients With Confirmed COVID-19 #MMPMID33060413
  • Bozkurt E; Ozates S; Muhafiz E; Yilmaz F; Caliskan O
  • Eye Contact Lens 2021[Apr]; 47 (4): 168-173 PMID33060413show ga
  • PURPOSE: To assess the effect of severe acute respiratory syndrome coronavirus-2 infection on the conjunctiva and tear film. METHODS: Thirty-eight patients with confirmed COVID-19 and 31 healthy controls were included in this prospective and observational study. Individuals with COVID-19 formed the patient group, and healthy individuals formed the control group. Conjunctival impression cytology (CIC), TBUT, Schirmer II test, and ocular surface disease index were evaluated in all participants. RESULTS: No significant difference was observed regarding the mean age and gender between the groups (P=0.786 and P=0.122, respectively). The mean TBUT and Schirmer II test results did not differ between the two groups (P=0.496 and P=0.447, respectively). The CIC results revealed decreased density and cell size of goblet cells and moderate to high enlargement, squamous changes, and increased nucleocytoplasmic ratio in nongoblet epithelial cells in the COVID-19 group compared with the control group. Based on the Nelson classification in CIC samples, 60.6% of the COVID-19 group and 19.4% of the control group had changes consistent with grade 2 or above. The presence of neutrophils in CIC was significantly higher in the COVID-19 group (P<0.001), whereas the presence of lymphocyte was similar between the two groups (P=0.247). CONCLUSION: This study revealed the pathological conjunctival alterations in patients with COVID-19 and demonstrated that pathological ocular surface alterations may present even at the beginning of COVID-19 without clinically significant ocular manifestation.
  • |Adult[MESH]
  • |COVID-19 Nucleic Acid Testing[MESH]
  • |COVID-19/*diagnosis[MESH]
  • |Cell Count[MESH]
  • |Cell Size[MESH]
  • |Conjunctiva/*pathology[MESH]
  • |Conjunctivitis, Viral/*diagnosis/virology[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Cytological Techniques[MESH]
  • |Dry Eye Syndromes/*diagnosis/virology[MESH]
  • |Eye Infections, Viral/*diagnosis/virology[MESH]
  • |Female[MESH]
  • |Goblet Cells/pathology[MESH]
  • |Humans[MESH]
  • |Lymphocytes/pathology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Neutrophils/pathology[MESH]
  • |Prospective Studies[MESH]
  • |SARS-CoV-2/genetics/*isolation & purification[MESH]
  • |Tears/*virology[MESH]


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