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10.1097/MAT.0000000000001325

http://scihub22266oqcxt.onion/10.1097/MAT.0000000000001325
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33060407!7846248!33060407
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suck abstract from ncbi


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pmid33060407      ASAIO+J 2021 ; 67 (2): 125-131
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  • SARS-CoV-2 Versus Influenza-associated Acute Respiratory Distress Syndrome Requiring Veno-venous Extracorporeal Membrane Oxygenation Support #MMPMID33060407
  • Cousin N; Bourel C; Carpentier D; Goutay J; Mugnier A; Labreuche J; Godeau E; Clavier T; Grange S; Tamion F; Durand A; Moussa MD; Duburcq T
  • ASAIO J 2021[Feb]; 67 (2): 125-131 PMID33060407show ga
  • No study has compared patients with COVID-19-related refractory ARDS requiring veno-venous extracorporeal membrane oxygenation (V-V ECMO) to a relevant and homogenous control population. We aimed to compare the outcomes, the clinical characteristics, and the adverse effects of COVID-19 patients to a retrospective cohort of influenza patients. This retrospective case-control study was conducted in the ICUs of Lille and Rouen University Hospitals between January 2014 and May 2020. Two independent cohorts of patients with ARDS requiring V-V ECMO infected with either COVID-19 (n = 30) or influenza (n = 22) were compared. A 3-month follow-up was completed for all patients. Median age of COVID-19 and influenza patients was similar (57 vs. 55 years; p = 0.62). The 28-day mortality rate did not significantly differ between COVID-19 (43.3%) and influenza patients (50%, p = 0.63). There was no significant difference considering the cumulative incidence of ECMO weaning, hospital discharge, and 3-month survival. COVID-19 patients had a lower SAPS II score (58 [37-64] vs. 68 [52-83]; p = 0.039), a higher body mass index (33 [29-38] vs. 30 [26-34] kg/m2; p = 0.05), and were cannulated later (median delay between mechanical support and V-V ECMO 6 vs. 3 days, p = 0.004) compared with influenza patients. No difference in overall adverse events was observed between COVID-19 and influenza patients (70% vs. 95.5% respectively; p = 0.23). Despite differences in clinical presentation before V-V ECMO implantation, 28-day and 3-month mortality rate did not differ between COVID-19 and influenza patients. Considering the lack of specific treatment for COVID-19, V-V ECMO should be considered as a relevant rescue organ support.
  • |*Extracorporeal Membrane Oxygenation/adverse effects[MESH]
  • |COVID-19/*complications[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Influenza, Human/*complications[MESH]
  • |Intensive Care Units[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Respiratory Distress Syndrome/etiology/*therapy[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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