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Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Science 2020 ; 370 (6521): ä Nephropedia Template TP
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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms #MMPMID33060197
Gordon DE; Hiatt J; Bouhaddou M; Rezelj VV; Ulferts S; Braberg H; Jureka AS; Obernier K; Guo JZ; Batra J; Kaake RM; Weckstein AR; Owens TW; Gupta M; Pourmal S; Titus EW; Cakir M; Soucheray M; McGregor M; Cakir Z; Jang G; O'Meara MJ; Tummino TA; Zhang Z; Foussard H; Rojc A; Zhou Y; Kuchenov D; Huttenhain R; Xu J; Eckhardt M; Swaney DL; Fabius JM; Ummadi M; Tutuncuoglu B; Rathore U; Modak M; Haas P; Haas KM; Naing ZZC; Pulido EH; Shi Y; Barrio-Hernandez I; Memon D; Petsalaki E; Dunham A; Marrero MC; Burke D; Koh C; Vallet T; Silvas JA; Azumaya CM; Billesbolle C; Brilot AF; Campbell MG; Diallo A; Dickinson MS; Diwanji D; Herrera N; Hoppe N; Kratochvil HT; Liu Y; Merz GE; Moritz M; Nguyen HC; Nowotny C; Puchades C; Rizo AN; Schulze-Gahmen U; Smith AM; Sun M; Young ID; Zhao J; Asarnow D; Biel J; Bowen A; Braxton JR; Chen J; Chio CM; Chio US; Deshpande I; Doan L; Faust B; Flores S; Jin M; Kim K; Lam VL; Li F; Li J; Li YL; Li Y; Liu X; Lo M; Lopez KE; Melo AA; Moss FR 3rd; Nguyen P; Paulino J; Pawar KI; Peters JK; Pospiech TH Jr; Safari M; Sangwan S; Schaefer K; Thomas PV; Thwin AC; Trenker R; Tse E; Tsui TKM; Wang F; Whitis N; Yu Z; Zhang K; Zhang Y; Zhou F; Saltzberg D; Hodder AJ; Shun-Shion AS; Williams DM; White KM; Rosales R; Kehrer T; Miorin L; Moreno E; Patel AH; Rihn S; Khalid MM; Vallejo-Gracia A; Fozouni P; Simoneau CR; Roth TL; Wu D; Karim MA; Ghoussaini M; Dunham I; Berardi F; Weigang S; Chazal M; Park J; Logue J; McGrath M; Weston S; Haupt R; Hastie CJ; Elliott M; Brown F; Burness KA; Reid E; Dorward M; Johnson C; Wilkinson SG; Geyer A; Giesel DM; Baillie C; Raggett S; Leech H; Toth R; Goodman N; Keough KC; Lind AL; Klesh RJ; Hemphill KR; Carlson-Stevermer J; Oki J; Holden K; Maures T; Pollard KS; Sali A; Agard DA; Cheng Y; Fraser JS; Frost A; Jura N; Kortemme T; Manglik A; Southworth DR; Stroud RM; Alessi DR; Davies P; Frieman MB; Ideker T; Abate C; Jouvenet N; Kochs G; Shoichet B; Ott M; Palmarini M; Shokat KM; Garcia-Sastre A; Rassen JA; Grosse R; Rosenberg OS; Verba KA; Basler CF; Vignuzzi M; Peden AA; Beltrao P; Krogan NJ
Science 2020[Dec]; 370 (6521): ä PMID33060197show ga
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analyses for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARS-CoV-2 ORF9b, an interaction we structurally characterized using cryo-electron microscopy. Combining genetically validated host factors with both COVID-19 patient genetic data and medical billing records identified molecular mechanisms and potential drug treatments that merit further molecular and clinical study.
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Science 2020 ; 370 (6521): ä
