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10.1183/13993003.02737-2020

http://scihub22266oqcxt.onion/10.1183/13993003.02737-2020
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33060154!7562695!33060154
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suck abstract from ncbi


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pmid33060154      Eur+Respir+J 2021 ; 57 (2): ä
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  • mTORC1 hyperactivation in lymphangioleiomyomatosis leads to ACE2 upregulation in type II pneumocytes: implications for COVID-19 #MMPMID33060154
  • Tang Y; Kwiatkowski DJ; Henske EP
  • Eur Respir J 2021[Feb]; 57 (2): ä PMID33060154show ga
  • Increased pneumocyte expression of the SARS-CoV-2 entry receptor ACE2 in lymphangioleiomyomatosis (LAM) is associated with upregulation of interferon pathways in natural killer cells as well as increased IL6 expression in LAM-associated fibroblasts https://bit.ly/34ChSsg
  • |*Alveolar Epithelial Cells/metabolism/pathology[MESH]
  • |*COVID-19/metabolism/virology[MESH]
  • |*Lymphangioleiomyomatosis/metabolism/pathology[MESH]
  • |Angiotensin-Converting Enzyme 2/*genetics[MESH]
  • |Antibiotics, Antineoplastic/pharmacology[MESH]
  • |Cancer-Associated Fibroblasts/metabolism[MESH]
  • |Humans[MESH]
  • |Interferons/metabolism[MESH]
  • |Interleukin-6/metabolism[MESH]
  • |Mechanistic Target of Rapamycin Complex 1/*metabolism[MESH]
  • |SARS-CoV-2/physiology[MESH]
  • |Signal Transduction/drug effects[MESH]
  • |Sirolimus/*pharmacology[MESH]


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