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10.1016/j.clinph.2020.09.008 http://scihub22266oqcxt.onion/10.1016/j.clinph.2020.09.008 33060058!7527310!33060058     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Neurophysiol 2021 ; 132 (1): 218-225 Nephropedia Template TP {{tp|p=33060058|t=2021. Alpha coma EEG pattern in patients with severe COVID-19 related encephalopathy |pdf=|usr=}}{{33060058}} gab.com Text Alpha coma EEG pattern in patients with severe COVID-19 related encephalopathy JO: Clin Neurophysiol http://www.kidney.de/pget.php?&tw=1&pmid=33060058 #FOAvip OBJECTIVE: Encephalopathy is a major neurological complication of severe Coronavirus Disease 2019 (COVID-19), but has not been fully defined yet. Further, it remains unclear whether neurological manifestations are primarily due to neurotropism of the virus, or indirect effects, like cerebral hypoxia. METHODS: We analysed the electroencephalograms (EEGs) of 19 consecutive patients with laboratory-confirmed COVID-19, performed at peak disease severity as part of their clinical management. Disease severity, respiratory failure, immune and metabolic dysfunction, sedation status, and neurological examination on the day of the EEG were noted. RESULTS: Severe encephalopathy was confirmed in 13 patients, all with severe COVID-19; 10 remained comatose off sedation, and five of them had alpha coma (AC). Disease severity, sedation, immune and metabolic dysfunction were not different between those with AC and those without. CONCLUSIONS: Severe COVID-19 encephalopathy is a principal cause of persisting coma after sedation withdrawal. The relatively high incidence of the rare AC pattern may reflect direct SARS-CoV-2 neurotropism with a predilection for the brainstem ascending reticular system. SIGNIFICANCE: Systematic early EEG detection of encephalopathy related to severe COVID-19 is important for the acute care and the management of long-term neurological and cognitive sequelae, and may help our better understanding of its pathophysiology. Twit Text FOAVip Alpha coma EEG pattern in patients with severe COVID-19 related encephalopathy ????Clin Neurophysiol http://www.kidney.de/pget.php?&tw=1&pmid=33060058 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33060058 #FOAvip English Wikipedia <ref>{{Cite pmid|33060058}}</ref> Alpha coma EEG pattern in patients with severe COVID-19 related encephalopathy #MMPMID33060058 Koutroumanidis M; Gratwicke J; Sharma S; Whelan A; Tan SV; Glover G Clin Neurophysiol 2021[Jan]; 132 (1): 218-225 PMID33060058show ga OBJECTIVE: Encephalopathy is a major neurological complication of severe Coronavirus Disease 2019 (COVID-19), but has not been fully defined yet. Further, it remains unclear whether neurological manifestations are primarily due to neurotropism of the virus, or indirect effects, like cerebral hypoxia. METHODS: We analysed the electroencephalograms (EEGs) of 19 consecutive patients with laboratory-confirmed COVID-19, performed at peak disease severity as part of their clinical management. Disease severity, respiratory failure, immune and metabolic dysfunction, sedation status, and neurological examination on the day of the EEG were noted. RESULTS: Severe encephalopathy was confirmed in 13 patients, all with severe COVID-19; 10 remained comatose off sedation, and five of them had alpha coma (AC). Disease severity, sedation, immune and metabolic dysfunction were not different between those with AC and those without. CONCLUSIONS: Severe COVID-19 encephalopathy is a principal cause of persisting coma after sedation withdrawal. The relatively high incidence of the rare AC pattern may reflect direct SARS-CoV-2 neurotropism with a predilection for the brainstem ascending reticular system. SIGNIFICANCE: Systematic early EEG detection of encephalopathy related to severe COVID-19 is important for the acute care and the management of long-term neurological and cognitive sequelae, and may help our better understanding of its pathophysiology. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Brain Diseases/etiology/*physiopathology[MESH] |Brain/*physiopathology[MESH] |COVID-19/complications/*physiopathology[MESH] |Coma/etiology/*physiopathology[MESH] |Electroencephalography[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH]Alpha coma EEG pattern in patients with severe COVID-19 related enceph(epmc).pdf DeepDyve Pubget Overpricing