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10.1016/j.acthis.2020.151634

http://scihub22266oqcxt.onion/10.1016/j.acthis.2020.151634
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33059115!7550172!33059115
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suck abstract from ncbi


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pmid33059115      Acta+Histochem 2020 ; 122 (8): 151634
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  • Comparison of similar cells: Mesenchymal stromal cells and fibroblasts #MMPMID33059115
  • Ugurlu B; Karaoz E
  • Acta Histochem 2020[Dec]; 122 (8): 151634 PMID33059115show ga
  • Almost from all organs, both mesenchymal stromal cells and fibroblasts can be isolated. Mesenchymal stromal cells (MSCs) are the most preferred cellular therapeutic agents with the regenerative potential, and fibroblasts are one of the most abundant cell types with the ability to maintain homeostasis. Because of the promising properties of MSCs, they have been well studied and their differentiation potentials, immunomodulatory potentials, gene expression profiles are identified. It has been observed that fibroblasts and mesenchymal stromal cells have similar morphology, gene expression patterns, surface markers, proliferation, differentiation, and immunomodulatory capacities. Thus, it is hard to distinguish these two cell types. Epigenetic signatures, i.e., methylation patterns of cells, are the only usable promising difference between them. Such significant similarities show that these two cells may be related to each other.
  • |*Epigenesis, Genetic[MESH]
  • |Antigens, CD/genetics/immunology[MESH]
  • |Autoimmune Diseases/genetics/immunology/pathology/*therapy[MESH]
  • |Biomarkers/metabolism[MESH]
  • |Cell Differentiation[MESH]
  • |Cell Lineage[MESH]
  • |Cell Proliferation[MESH]
  • |Cell- and Tissue-Based Therapy/methods[MESH]
  • |DNA Methylation[MESH]
  • |Fibroblasts/*cytology/immunology/transplantation[MESH]
  • |Gene Expression[MESH]
  • |Humans[MESH]
  • |Immunomodulation[MESH]
  • |Mesenchymal Stem Cell Transplantation/methods[MESH]
  • |Mesenchymal Stem Cells/*cytology/immunology[MESH]
  • |Nervous System Diseases/genetics/immunology/pathology/*therapy[MESH]


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