Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.str.2020.10.001 http://scihub22266oqcxt.onion/10.1016/j.str.2020.10.001 33058760!7557167!33058760     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Structure 2020 ; 28 (11): 1218-1224.e4 Nephropedia Template TP {{tp|p=33058760|t=2020. The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET |pdf=|usr=}}{{33058760}} gab.com Text The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET JO: Structure http://www.kidney.de/pget.php?&tw=1&pmid=33058760 #FOAvip The ongoing global pandemic of coronavirus disease 2019 (COVID-19) resulted from the outbreak of SARS-CoV-2 in December 2019. Currently, multiple efforts are being made to rapidly develop vaccines and treatments to fight COVID-19. Current vaccine candidates use inactivated SARS-CoV-2 viruses; therefore, it is important to understand the architecture of inactivated SARS-CoV-2. We have genetically and structurally characterized beta-propiolactone-inactivated viruses from a propagated and purified clinical strain of SARS-CoV-2. We observed that the virus particles are roughly spherical or moderately pleiomorphic. Although a small fraction of prefusion spikes are found, most spikes appear nail shaped, thus resembling a postfusion state, where the S1 protein of the spike has disassociated from S2. Cryoelectron tomography and subtomogram averaging of these spikes yielded a density map that closely matches the overall structure of the SARS-CoV postfusion spike and its corresponding glycosylation site. Our findings have major implications for SARS-CoV-2 vaccine design, especially those using inactivated viruses. Twit Text FOAVip The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET ????Structure http://www.kidney.de/pget.php?&tw=1&pmid=33058760 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33058760 #FOAvip English Wikipedia <ref>{{Cite pmid|33058760}}</ref> The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET #MMPMID33058760 Liu C; Mendonca L; Yang Y; Gao Y; Shen C; Liu J; Ni T; Ju B; Liu C; Tang X; Wei J; Ma X; Zhu Y; Liu W; Xu S; Liu Y; Yuan J; Wu J; Liu Z; Zhang Z; Liu L; Wang P; Zhang P Structure 2020[Nov]; 28 (11): 1218-1224.e4 PMID33058760show ga The ongoing global pandemic of coronavirus disease 2019 (COVID-19) resulted from the outbreak of SARS-CoV-2 in December 2019. Currently, multiple efforts are being made to rapidly develop vaccines and treatments to fight COVID-19. Current vaccine candidates use inactivated SARS-CoV-2 viruses; therefore, it is important to understand the architecture of inactivated SARS-CoV-2. We have genetically and structurally characterized beta-propiolactone-inactivated viruses from a propagated and purified clinical strain of SARS-CoV-2. We observed that the virus particles are roughly spherical or moderately pleiomorphic. Although a small fraction of prefusion spikes are found, most spikes appear nail shaped, thus resembling a postfusion state, where the S1 protein of the spike has disassociated from S2. Cryoelectron tomography and subtomogram averaging of these spikes yielded a density map that closely matches the overall structure of the SARS-CoV postfusion spike and its corresponding glycosylation site. Our findings have major implications for SARS-CoV-2 vaccine design, especially those using inactivated viruses. |Animals[MESH] |Betacoronavirus/drug effects/immunology/*ultrastructure[MESH] |COVID-19 Vaccines[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/immunology/prevention & control[MESH] |Cryoelectron Microscopy[MESH] |Disinfectants/*pharmacology[MESH] |Electron Microscope Tomography[MESH] |Humans[MESH] |Propiolactone/*pharmacology[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/ultrastructure[MESH] |Vaccines, Inactivated/immunology[MESH] |Vero Cells[MESH] |Viral Vaccines/immunology[MESH]The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Reve(epmc).pdf DeepDyve Pubget Overpricing